Predictive Values of Blood Pressure and Arterial Stiffness in Institutionalized Very Aged Population (PARTAGE)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00901355|
Recruitment Status : Completed
First Posted : May 13, 2009
Last Update Posted : July 30, 2015
Introduction: High blood pressure especially systolic hypertension is a common condition in the elderly and is considered as a major determinant not only of cardiovascular (CV) morbidity and mortality, but also of several other age-related diseases, frailty and loss of autonomy. Actually, the association between BP levels and morbidity and mortality in the very elderly persons with several co-morbidities remains a controversial issue
Objectives: The aim of the PARTAGE study (Predictive values of blood pressure and arterial stiffness in institutionalized very aged population)is to determine the predictive value of blood pressure (BP) and arterial stiffness for overall mortality, major cardiovascular events and cognitive decline in a large population of institutionalized subjects aged 80 and over.
Methods: The population is composed of 1130 subjects aged over 80, living in nursing home, included by four french university hospitals centre (Nancy, Dijon, Paris, Toulouse) and two Italian (Cesena, Verona). Subjects with severe dementia and a very low level of autonomy are excluded from the study During the first visit, blood pressure were measured using an automatic monitor by physician in sitting and standing position (clinical BP and Orthostatic BP) and by a self measurement of blood pressure 3 measurements, in the morning and the evening, during 3 consecutive days).
Arterial stiffness is evaluated by measuring the carotid-femoral and carotid-radial pulse wave velocity (PWV) with the PulsePen® automatic device. Deaths and cardiovascular events are recorded during a follow-up of 2 years.
The hypothesis of the PARTAGE longitudinal study is that in very elderly frail individuals with multiple co-morbidities, CV risk could be better evaluated by combining self-measurements of BP and direct evaluation of arterial stiffness which are less influenced by the above mentioned disease and co-morbidities.
|Condition or disease|
|Hypertension Elderly Cardiovascular Mortality Cognitive Impairment Morbidity|
Show Detailed Description
|Study Type :||Observational|
|Actual Enrollment :||1130 participants|
|Official Title:||Morbidity and Mortality Based on Blood Pressure and Arterial Stiffness in Institutionalized Persons Aged 80 and Over: Study PARTAGE (Predictive Values of Blood Pressure and Arterial Stiffness in Institutionalized Very Aged Population).|
|Study Start Date :||January 2007|
|Actual Primary Completion Date :||December 2013|
|Actual Study Completion Date :||December 2013|
- Total Mortality [ Time Frame: 2 years Follow-up ]
- Cardiovascular morbidity Cognitive decline [ Time Frame: 2 years follow-up ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00901355
|University hospital of Dijon (Centre de Champmaillot)|
|Dijon, France, 21000|
|Hôpital La Grave|
|Toulouse, France, 31000|
|University hospital of Nancy|
|Vandoeuvre-les-Nancy, France, 54500|
|Hospital of Cesena|
|Civil hospital Maggiore (Geriatrics)|
|Principal Investigator:||Athanase BENETOS, Professor||University Hospital of Nancy, department of geriatrics.|