Studying Tissue Samples to Learn More About Drug Resistance in Patients With Acute Myeloid Leukemia
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|ClinicalTrials.gov Identifier: NCT00900380|
Recruitment Status : Completed
First Posted : May 12, 2009
Last Update Posted : May 19, 2017
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about cancer and the development of drug resistance in patients.
PURPOSE: This laboratory study is examining tissue samples from patients with acute myeloid leukemia to learn more about drug resistance in these patients.
|Condition or disease||Intervention/treatment|
|Leukemia||Other: flow cytometry Other: immunological diagnostic method Other: laboratory biomarker analysis|
- Ascertain whether assessments of P-glycoprotein (P-gp) status using the accumulation assay find greater than 10% positive specimens among 30 specimens (collected from patients with acute myeloid leukemia enrolled on clinical trial ECOG-E3999) found to be negative using only the efflux assay.
OUTLINE: This is a multicenter study.
Cryopreserved bone marrow specimens are examined for P-glycoprotein (P-gp) by the accumulation assay and the efflux assay using DiOC_2 dye. Flow cytometry is used for measuring activity in both assays.
PROJECTED ACCRUAL: A total of 40 specimens will be accrued for this study.
|Study Type :||Observational|
|Actual Enrollment :||40 participants|
|Official Title:||Comparison of P-gp Efflux and Accumulation Assay Results With ECOG 3999 Leukemia Samples|
|Actual Study Start Date :||March 28, 2006|
|Actual Primary Completion Date :||December 30, 2013|
|Actual Study Completion Date :||December 30, 2013|
- Percentage of specimens collected from patients that are found to be P-glycoprotein (P-gp)-positive by accumulation assay that were found to be negative using efflux assay [ Time Frame: 1 day ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00900380
|Study Chair:||Elisabeth Paietta, PhD||Our Lady of Mercy Medical Center|