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Studying Tumor Tissue Samples From Patients With Soft Tissue Sarcoma

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00900341
First Posted: May 12, 2009
Last Update Posted: March 21, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
University of Arizona
  Purpose

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at tumor tissue samples from patients with soft tissue sarcoma.


Condition Intervention
Sarcoma Genetic: DNA analysis Genetic: gene expression analysis Genetic: protein expression analysis Genetic: reverse transcriptase-polymerase chain reaction Genetic: western blotting Other: immunohistochemistry staining method Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: LABORATORY STUDIES OF SOFT TISSUE SARCOMAS

Resource links provided by NLM:


Further study details as provided by University of Arizona:

Primary Outcome Measures:
  • Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS [ Time Frame: 3 months ]

Enrollment: 27
Study Start Date: August 2005
Study Completion Date: June 2013
Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

  • To develop a pilot program for the collection, archiving, and experimental analyses of soft tissue sarcomas (STS).
  • To obtain STS tumors from cancer patients undergoing tumor removal or core needle biopsies.
  • To evaluate cellular and molecular factors involved in STS oncogenesis by studying samples derived from human tumor specimens.
  • To develop an accompanying bioinformatics database of the demographics of STS patients from which tumor specimens are derived for experimental study.

OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA interference, and Western blot or immunoprecipitation.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients undergoing surgical treatment for soft tissue sarcomas removal or core needle biopsy for medically indicated diagnostic or therapeutic purposes.
Criteria

DISEASE CHARACTERISTICS:

  • Meets one of the following criteria:

    • Patients with soft tissue sarcoma (STS) undergoing evaluation, treatment, and/or follow-up at the Arizona Cancer Center or University Medical Center
    • Patients undergoing surgical treatment for STS removal or core needle biopsy for medically indicated diagnostic or therapeutic purposes

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00900341


Locations
United States, Arizona
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, United States, 85724-5024
Sponsors and Collaborators
University of Arizona
National Cancer Institute (NCI)
Investigators
Principal Investigator: Lee D. Cranmer, MD, PhD University of Arizona
  More Information

Responsible Party: University of Arizona
ClinicalTrials.gov Identifier: NCT00900341     History of Changes
Other Study ID Numbers: 05-0509-04
P30CA023074 ( U.S. NIH Grant/Contract )
UARIZ-HSCA0535 ( Other Identifier: CDR0000597591 )
UARIZ-17879
First Submitted: May 9, 2009
First Posted: May 12, 2009
Last Update Posted: March 21, 2014
Last Verified: March 2014

Keywords provided by University of Arizona:
adult soft tissue sarcoma
childhood soft tissue sarcoma

Additional relevant MeSH terms:
Sarcoma
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms