Studying Tumor Tissue Samples From Patients With Soft Tissue Sarcoma

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00900341
Recruitment Status : Completed
First Posted : May 12, 2009
Last Update Posted : March 21, 2014
National Cancer Institute (NCI)
Information provided by (Responsible Party):
University of Arizona

Brief Summary:

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at tumor tissue samples from patients with soft tissue sarcoma.

Condition or disease Intervention/treatment
Sarcoma Genetic: DNA analysis Genetic: gene expression analysis Genetic: protein expression analysis Genetic: reverse transcriptase-polymerase chain reaction Genetic: western blotting Other: immunohistochemistry staining method Other: laboratory biomarker analysis

Detailed Description:


  • To develop a pilot program for the collection, archiving, and experimental analyses of soft tissue sarcomas (STS).
  • To obtain STS tumors from cancer patients undergoing tumor removal or core needle biopsies.
  • To evaluate cellular and molecular factors involved in STS oncogenesis by studying samples derived from human tumor specimens.
  • To develop an accompanying bioinformatics database of the demographics of STS patients from which tumor specimens are derived for experimental study.

OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA interference, and Western blot or immunoprecipitation.

Study Type : Observational
Actual Enrollment : 27 participants
Observational Model: Case-Only
Time Perspective: Prospective
Study Start Date : August 2005
Actual Primary Completion Date : June 2013
Actual Study Completion Date : June 2013

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Primary Outcome Measures :
  1. Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS [ Time Frame: 3 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients undergoing surgical treatment for soft tissue sarcomas removal or core needle biopsy for medically indicated diagnostic or therapeutic purposes.


  • Meets one of the following criteria:

    • Patients with soft tissue sarcoma (STS) undergoing evaluation, treatment, and/or follow-up at the Arizona Cancer Center or University Medical Center
    • Patients undergoing surgical treatment for STS removal or core needle biopsy for medically indicated diagnostic or therapeutic purposes


  • Not specified


  • Not specified

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00900341

United States, Arizona
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, United States, 85724-5024
Sponsors and Collaborators
University of Arizona
National Cancer Institute (NCI)
Principal Investigator: Lee D. Cranmer, MD, PhD University of Arizona

Responsible Party: University of Arizona Identifier: NCT00900341     History of Changes
Other Study ID Numbers: 05-0509-04
P30CA023074 ( U.S. NIH Grant/Contract )
UARIZ-HSCA0535 ( Other Identifier: CDR0000597591 )
First Posted: May 12, 2009    Key Record Dates
Last Update Posted: March 21, 2014
Last Verified: March 2014

Keywords provided by University of Arizona:
adult soft tissue sarcoma
childhood soft tissue sarcoma

Additional relevant MeSH terms:
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type