Studying Tumor Tissue Samples From Patients With Soft Tissue Sarcoma
|ClinicalTrials.gov Identifier: NCT00900341|
Recruitment Status : Completed
First Posted : May 12, 2009
Last Update Posted : March 21, 2014
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at tumor tissue samples from patients with soft tissue sarcoma.
|Condition or disease||Intervention/treatment|
|Sarcoma||Genetic: DNA analysis Genetic: gene expression analysis Genetic: protein expression analysis Genetic: reverse transcriptase-polymerase chain reaction Genetic: western blotting Other: immunohistochemistry staining method Other: laboratory biomarker analysis|
- To develop a pilot program for the collection, archiving, and experimental analyses of soft tissue sarcomas (STS).
- To obtain STS tumors from cancer patients undergoing tumor removal or core needle biopsies.
- To evaluate cellular and molecular factors involved in STS oncogenesis by studying samples derived from human tumor specimens.
- To develop an accompanying bioinformatics database of the demographics of STS patients from which tumor specimens are derived for experimental study.
OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA interference, and Western blot or immunoprecipitation.
|Study Type :||Observational|
|Actual Enrollment :||27 participants|
|Official Title:||LABORATORY STUDIES OF SOFT TISSUE SARCOMAS|
|Study Start Date :||August 2005|
|Actual Primary Completion Date :||June 2013|
|Actual Study Completion Date :||June 2013|
- Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS [ Time Frame: 3 months ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00900341
|United States, Arizona|
|Arizona Cancer Center at University of Arizona Health Sciences Center|
|Tucson, Arizona, United States, 85724-5024|
|Principal Investigator:||Lee D. Cranmer, MD, PhD||University of Arizona|