Cyclooxygenase-2 Expression in Tissue Samples From Patients With a Normal Cervix, Cervical Intraepithelial Neoplasia, or Early Invasive Cervical Cancer
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|ClinicalTrials.gov Identifier: NCT00900081|
Recruitment Status : Withdrawn (no accrual, PI left institution)
First Posted : May 12, 2009
Last Update Posted : August 1, 2017
RATIONALE: Studying samples of tissue from patients with or without cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This laboratory study is looking at cyclooxygenase-2 expression in tissue samples from patients with a normal cervix, cervical intraepithelial neoplasia, or early invasive cervical cancer.
|Condition or disease||Intervention/treatment|
|Cervical Cancer Precancerous Condition||Other: immunohistochemistry staining method Other: laboratory biomarker analysis Other: medical chart review|
- Determine cyclooxygenase-2 (COX-2) levels in biopsy or surgical specimens from patients with normal cervical epithelium, cervical intraepithelial neoplasia, or microinvasive squamous cell carcinoma of the cervix.
- Correlate COX-2 levels with histological diagnosis and parameters of invasion (i.e., matrix metalloproteinase, microvessel count, and VEGF).
OUTLINE: Paraffin-embedded tissue samples are analyzed by immunohistochemistry for evaluation of cyclooxygenase-2 levels, microvessel count, and matrix metalloproteinase and VEGF expression.
Medical data for study analysis is obtained by retrospective review of patient charts.
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Official Title:||Evaluation of Cyclooxygenase-2 Expression in Normal Cervix, Cervical Intraepithelial Neoplasia and Early Invasive Squamous Cell Carcinoma With Correlation to Parameters of Invasion and Angiogenesis|
|Actual Study Start Date :||May 2003|
|Primary Completion Date :||May 2003|
|Study Completion Date :||May 2003|
- Cyclooxygenase-2 (COX-2) levels in cervical intraepithelial neoplasia (CIN) [ Time Frame: day 1 ]
- Correlation of COX-2 levels in CIN with histological diagnosis and parameters of invasion [ Time Frame: Day 1 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00900081
|Study Chair:||Brigitte E. Miller, MD||Wake Forest University Health Sciences|