Epidermal Growth Factor Receptor Mutations in the Blood of Patients With Advanced Non-Small Cell Lung Cancer
Recruitment status was: Recruiting
RATIONALE: Collecting and storing samples of blood from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at epidermal growth factor receptor mutations in the blood of patients with advanced non-small cell lung cancer.
|Official Title:||Study of Mutations of Epidermal Growth Factor Receptor in the Blood of Patients With Advanced Non Small Cell Lung Cancer|
- Existence of epidermal growth factor receptor (EGFR) mutations in peripheral blood
- Frequency of EGFR mutation
- Correlation of the presence of EGFR mutation in blood with EFGR mutation in primary or metastatic tumor tissue
|Study Start Date:||June 2006|
- Determine if epidermal growth factor receptor (EGFR) mutation exists in the peripheral blood of patients with advanced non-small cell lung cancer (NSCLC).
- Estimate the frequency of EGFR mutation in these patients.
- Correlate the presence of EGFR mutation in blood with EGFR mutation in primary or metastatic NSCLC tumor block.
OUTLINE: Patients undergo blood collection for analysis of epidermal growth factor receptor mutation by DNA sequencing.
PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00899756
|Johns Hopkins Singapore International Medical Centre|
|Singapore, Singapore, 308433|
|Study Chair:||Alex Y. Chang, MD||Johns Hopkins Singapore International Medical Centre|