Proteases in Patients With Prostate Cancer That Has Spread to the Bone
RATIONALE: Collecting and storing samples of bone marrow and tissue from patients to test in the laboratory may help the study of cancer.
PURPOSE: This laboratory study is comparing proteases (enzymes that break down protein) in patients with prostate cancer that has spread to the bone with patients who do not have cancer that has spread to the bone.
Genetic: fluorescence in situ hybridization
Genetic: microarray analysis
Genetic: molecular diagnostic method
Other: immunohistochemistry staining method
Other: laboratory biomarker analysis
|Official Title:||Proteases in Prostate Cancer Bone Metastasis|
- Expression and activity of proteases and related molecules [ Designated as safety issue: No ]
|Study Start Date:||July 2001|
|Study Completion Date:||January 2008|
|Primary Completion Date:||September 2006 (Final data collection date for primary outcome measure)|
- Examine the roles of proteases and protease-associated molecules in bone metastases in patients with metastatic prostate cancer.
OUTLINE: Patients undergo bone marrow aspiration and core bone biopsies. Tissues are analyzed by immunohistochemistry methods, in situ hybridization assays, gelatin zymography and/or Western blot analysis, and gene profiling analysis in order to visualize and quantitate protease or protease-related levels.
PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00899665
|United States, Michigan|
|Barbara Ann Karmanos Cancer Institute|
|Detroit, Michigan, United States, 48076|
|Study Chair:||Michael L. Cher, MD||Barbara Ann Karmanos Cancer Institute|