We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Tissue Sample Collection From Patients With Fanconi Anemia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00899522
First Posted: May 12, 2009
Last Update Posted: December 4, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Grover Bagby, OHSU Knight Cancer Institute
  Purpose

RATIONALE: Collecting and storing samples of tumor tissue from patients with Fanconi anemia to test in the laboratory may help the study of cancer in the future.

PURPOSE: This laboratory study is collecting and storing tumor tissue samples from patients with Fanconi anemia.


Condition Intervention
Fanconi Anemia Unspecified Adult Solid Tumor, Protocol Specific Unspecified Childhood Solid Tumor, Protocol Specific Other: biologic sample preservation procedure Procedure: biopsy

Study Type: Observational
Study Design: Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Fanconi Anemia Cancer Cell Repository

Resource links provided by NLM:


Further study details as provided by Grover Bagby, OHSU Knight Cancer Institute:

Primary Outcome Measures:
  • Creation of a Fanconi Anemia Cell Repository using rare solid tumor samples from patients with Fanconi anemia [ Time Frame: Duration of the study ]
  • Study tissue samples by molecular methods, including gene microarrays [ Time Frame: Duration of the study ]
  • Development of cancer cell lines from tissue archived from patients with Fanconi anemia [ Time Frame: Duration of the study ]

Enrollment: 8
Study Start Date: August 2005
Study Completion Date: May 2013
Primary Completion Date: March 2013 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: biologic sample preservation procedure
    Once the pathologist has taken the material needed to establish diagnosis of cancer, the anonymized snap-frozen and fresh samples will be either shipped to our laboratory for analysis or will be picked up by a member of the principal investigator's lab team. Samples will be stored indefinitely.
    Procedure: biopsy
    Once the pathologist has taken the material needed to establish diagnosis of cancer, 1-10 grams of the remaining tissue should be placed in phosphate buffered saline and shipped to the Bagby Lab.
Detailed Description:

OBJECTIVES:

  • Acquire rare solid tumor samples from patients with Fanconi anemia in order to create a Fanconi Anemia Cell Repository at the Oregon Health and Science University Cancer Institute.
  • Study repository tissue using a variety of molecular methods, including gene microarrays.
  • Develop cancer cell lines that are publicly available from tissue archived from patients with Fanconi anemia.

OUTLINE: Tumor biopsies are collected from patients with Fanconi anemia and archived for future molecular studies, cell line generation, and general usage by the research community at large. Medical information about the patient's cancer is also archived.

PROJECTED ACCRUAL: Not specified.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   1 Year to 55 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
To recruit participants into this project, an announcement will be posted on the Fanconi Anemia Research Fund website (http://www.fanconi.org/) after IRB approval is obtained.
Criteria

DISEASE CHARACTERISTICS:

  • Confirmed Fanconi anemia
  • Confirmed malignant solid tumor
  • Biopsy of tumor tissue available

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00899522


Locations
United States, Oregon
Knight Cancer Institute at Oregon Health and Science University
Portland, Oregon, United States, 97239-3098
Sponsors and Collaborators
OHSU Knight Cancer Institute
National Cancer Institute (NCI)
Investigators
Principal Investigator: Grover C. Bagby, MD OHSU Knight Cancer Institute
  More Information

Responsible Party: Grover Bagby, Professor Emeritus, OHSU Knight Cancer Institute
ClinicalTrials.gov Identifier: NCT00899522     History of Changes
Other Study ID Numbers: IRB00001100
P30CA069533 ( U.S. NIH Grant/Contract )
OHSU-HEM-03022-LX
OHSU-IRB00001100
OSHU-CR00003822
CDR0000445453 ( Other Identifier: NCI PDQ )
First Submitted: May 9, 2009
First Posted: May 12, 2009
Last Update Posted: December 4, 2017
Last Verified: November 2017

Keywords provided by Grover Bagby, OHSU Knight Cancer Institute:
Fanconi anemia
unspecified adult solid tumor, protocol specific
unspecified childhood solid tumor, protocol specific

Additional relevant MeSH terms:
Anemia
Fanconi Anemia
Anemia, Hypoplastic, Congenital
Anemia, Aplastic
Neoplasms
Fanconi Syndrome
Hematologic Diseases
Bone Marrow Diseases
Genetic Diseases, Inborn
DNA Repair-Deficiency Disorders
Metabolic Diseases
Renal Tubular Transport, Inborn Errors
Kidney Diseases
Urologic Diseases
Metabolism, Inborn Errors