Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00899340|
Recruitment Status : Completed
First Posted : May 12, 2009
Last Update Posted : April 2, 2013
RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx.
PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.
|Condition or disease||Intervention/treatment|
|Head and Neck Cancer||Genetic: gene expression analysis Genetic: microarray analysis Genetic: protein expression analysis Other: immunohistochemistry staining method Other: laboratory biomarker analysis|
- To investigate if some of the differences in gene expression are also reflected at the protein level.
- To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance.
- To identify targets for therapy.
OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.
|Study Type :||Observational|
|Actual Enrollment :||54 participants|
|Official Title:||Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma|
|Study Start Date :||May 2006|
|Actual Primary Completion Date :||March 2008|
|Actual Study Completion Date :||March 2008|
- Genetic: gene expression analysis
profiles of HPV(+) and (-) HNSCCs
- Genetic: microarray analysis
microarray analysisOther Name: SAM - significance Analysis of microarrays
- Genetic: protein expression analysis
protein expression analysis
- Other: immunohistochemistry staining method
immunohistochemistry staining method
- Other: laboratory biomarker analysis
laboratory biomarker analysis
- Development of biomarkers for early detection or recurrence surveillance [ Time Frame: after 7 months of tissue collection ]
- Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx [ Time Frame: after 7months of tissue collection ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00899340
|Study Chair:||Barbara Murphy, MD||Vanderbilt-Ingram Cancer Center|