Epidermal Growth Factor Receptor and K-ras Mutations in Patients With Stage III Non-Small Cell Lung Cancer
RATIONALE: Collecting and storing samples of tissue from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at epidermal growth factor receptor mutations and k-ras oncogene mutations in patients with stage III non-small cell lung cancer.
|Official Title:||Evaluation of EGFR and K-ras Mutations in Patients With Stage III NSCLC Treated on CALGB 30106|
- Frequency of epidermal growth factor receptor (EGFR) and K-ras mutations [ Designated as safety issue: No ]
- Correlate presence or absence of EGFR and/or K-ras mutations with radiographic response to treatment [ Designated as safety issue: No ]
|Study Start Date:||November 2005|
|Study Completion Date:||March 2006|
|Primary Completion Date:||March 2006 (Final data collection date for primary outcome measure)|
- Determine the frequency of epidermal growth factor receptor (EGFR) and K-ras mutations in patients with stage III non-small cell lung cancer (NSCLC) treated on CALGB 30106.
- Correlate presence or absence of EGFR and/or K-ras mutations with radiographic response to treatment in these patients.
OUTLINE: Tissue samples are analyzed for epidermal growth factor receptor and K-ras mutations.
PROJECTED ACCRUAL: A total of 49 patient specimens will be accrued for this study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00898924
|Study Chair:||Pasi Janne, MD, PhD||Dana-Farber Cancer Institute|