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Effect of Bevacizumab and VEGF on Platelet Clustering in Patients Who Are Receiving Bevacizumab for Cancer

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2011 by National Cancer Institute (NCI).
Recruitment status was:  Recruiting
Information provided by:
National Cancer Institute (NCI) Identifier:
First received: May 9, 2009
Last updated: August 6, 2013
Last verified: June 2011

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about the effect of bevacizumab and VEGF on platelet clustering.

PURPOSE: This research study is looking at the effect of bevacizumab and VEGF on platelet clustering in patients with cancer who are receiving bevacizumab.

Condition Intervention
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Childhood Solid Tumor, Protocol Specific
Biological: bevacizumab
Other: coagulation study
Other: laboratory biomarker analysis
Other: platelet aggregation test

Study Type: Observational
Official Title: Influence of Bevacizumab and VEGF on Platelet Aggregation

Resource links provided by NLM:

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Influence of bevacizumab on platelet aggregation
  • Influence of VEGF on platelet aggregation
  • Influence of VEGF or bevacizumab on cyclooxygenesis
  • Correlation between medication sequence and platelet aggregation

Estimated Enrollment: 20
Study Start Date: October 2007
Estimated Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Detailed Description:


  • To determine the influence of bevacizumab on platelet aggregation in patients receiving bevacizumab for cancer.
  • To determine the influence of VEGF on platelet aggregation.
  • To determine the influence of VEGF or bevacizumab on cyclooxygenesis.
  • To determine if the sequence of medication plays a role in platelet aggregation.

OUTLINE: Blood samples are collected before and after bevacizumab infusion. Samples are analyzed for measurements of platelet aggregation, coagulation parameters, and endothelial activation (e.g., fibrin fragment F1 and 2, thrombin and antithrombin complex, soluble P-selectin, Von Willebrand factor and factor VIII, tissue factor, and endothelin 1).


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


  • Receiving bevacizumab for cancer


  • Not specified


  • See Disease Characteristics
  Contacts and Locations
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Please refer to this study by its identifier: NCT00898794

Kantonsspital Graubuenden Recruiting
Chur, Switzerland, CH-7000
Contact: Roger von Moos, MD    41-81-256-6646   
Sponsors and Collaborators
Kantonsspital Graubuenden
Principal Investigator: Roger von Moos, MD Kantonsspital Graubuenden
  More Information Identifier: NCT00898794     History of Changes
Other Study ID Numbers: KSGR-GR-01-07
CDR0000631252 ( Registry Identifier: PDQ (Physician Data Query) )
Study First Received: May 9, 2009
Last Updated: August 6, 2013

Keywords provided by National Cancer Institute (NCI):
unspecified adult solid tumor, protocol specific
unspecified childhood solid tumor, protocol specific

Additional relevant MeSH terms:
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents processed this record on May 25, 2017