Effect of Bevacizumab and VEGF on Platelet Clustering in Patients Who Are Receiving Bevacizumab for Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00898794|
Recruitment Status : Unknown
Verified June 2011 by National Cancer Institute (NCI).
Recruitment status was: Recruiting
First Posted : May 12, 2009
Last Update Posted : August 7, 2013
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about the effect of bevacizumab and VEGF on platelet clustering.
PURPOSE: This research study is looking at the effect of bevacizumab and VEGF on platelet clustering in patients with cancer who are receiving bevacizumab.
|Condition or disease||Intervention/treatment|
|Unspecified Adult Solid Tumor, Protocol Specific Unspecified Childhood Solid Tumor, Protocol Specific||Biological: bevacizumab Other: coagulation study Other: laboratory biomarker analysis Other: platelet aggregation test|
- To determine the influence of bevacizumab on platelet aggregation in patients receiving bevacizumab for cancer.
- To determine the influence of VEGF on platelet aggregation.
- To determine the influence of VEGF or bevacizumab on cyclooxygenesis.
- To determine if the sequence of medication plays a role in platelet aggregation.
OUTLINE: Blood samples are collected before and after bevacizumab infusion. Samples are analyzed for measurements of platelet aggregation, coagulation parameters, and endothelial activation (e.g., fibrin fragment F1 and 2, thrombin and antithrombin complex, soluble P-selectin, Von Willebrand factor and factor VIII, tissue factor, and endothelin 1).
|Study Type :||Observational|
|Estimated Enrollment :||20 participants|
|Official Title:||Influence of Bevacizumab and VEGF on Platelet Aggregation|
|Study Start Date :||October 2007|
|Estimated Primary Completion Date :||May 2009|
- Influence of bevacizumab on platelet aggregation
- Influence of VEGF on platelet aggregation
- Influence of VEGF or bevacizumab on cyclooxygenesis
- Correlation between medication sequence and platelet aggregation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00898794
|Chur, Switzerland, CH-7000|
|Contact: Roger von Moos, MD 41-81-256-6646 firstname.lastname@example.org|
|Principal Investigator:||Roger von Moos, MD||Kantonsspital Graubuenden|