Biomarker Study of Blood Samples From Patients With Non-Small Cell Lung Cancer Treated With Carboplatin and Paclitaxel With or Without Bevacizumab
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|ClinicalTrials.gov Identifier: NCT00898417|
Recruitment Status : Completed
First Posted : May 12, 2009
Last Update Posted : May 19, 2017
RATIONALE: Studying samples of blood in the laboratory from patients undergoing treatment for non-small cell lung cancer may help doctors predict how patients will respond to treatment.
PURPOSE: This laboratory study is looking at proteomic patterns in stored blood samples from patients undergoing treatment for non-small cell lung cancer.
|Condition or disease||Intervention/treatment|
|Lung Cancer||Biological: bevacizumab Drug: carboplatin Drug: paclitaxel Genetic: proteomic profiling Other: laboratory biomarker analysis Other: matrix-assisted laser desorption/ionization time of flight mass spectrometry|
- To develop a serum proteomic classifier using matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry analysis of blood samples from patients with non-squamous cell non-small cell lung cancer to predict benefit, in terms of survival and time to progression, from treatment with bevacizumab in combination with carboplatin and paclitaxel.
- To better quantitate candidate biomarkers by using more advanced mass spectrometric technologies, including multiple-reaction monitoring and heavy-labeled peptides.
OUTLINE: Previously collected pre-treatment samples of serum or plasma are randomly selected from patients enrolled on protocol ECOG-4599 (i.e., 60 from the bevacizumab arm and 30 from the control arm). Samples are analyzed by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry to identify patterns from protein spectra that correlate with patient survival.
|Study Type :||Observational|
|Actual Enrollment :||90 participants|
|Official Title:||Development of a Serum Proteomic Classifier for the Prediction of Benefit From Bevacizumab in Combination With Carboplatin and Paclitaxel|
|Actual Study Start Date :||March 14, 2008|
|Actual Primary Completion Date :||April 14, 2008|
|Actual Study Completion Date :||April 14, 2008|
U.S. FDA Resources
- Survival [ Time Frame: 1 day ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00898417
|Study Chair:||David P. Carbone, MD, PhD||Vanderbilt-Ingram Cancer Center|