Blood and Tissue Sample Collection for Future Colon Cancer Biomarker Studies in Patients Undergoing Colonoscopy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00897403
Recruitment Status : Completed
First Posted : May 12, 2009
Last Update Posted : April 7, 2017
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Daniel Liebler, Vanderbilt University Medical Center

Brief Summary:

RATIONALE: Collecting and storing samples of blood and tissue from patients undergoing colonoscopy to study in the laboratory may help doctors learn more about colon cancer and identify biomarkers related to colon cancer in the future.

PURPOSE: This laboratory study is collecting blood and tissue samples for future colon cancer biomarker studies in patients undergoing colonoscopy.

Condition or disease Intervention/treatment
Colorectal Cancer Health Status Unknown Other: biologic sample preservation procedure Procedure: diagnostic colonoscopy

Detailed Description:


  • Collect blood and tissue samples (including polyps, abnormal growths, cancer, and normal tissue) from patients undergoing colonoscopy.

OUTLINE: Patients undergo blood and tissue sample collection during colonoscopy. Samples are stored for future biomarker proteomic profiling.

Study Type : Observational
Actual Enrollment : 6446 participants
Time Perspective: Prospective
Official Title: Discovery of Candidate Biomarkers in Colon Cancer and Precancers Repository
Actual Study Start Date : December 2006
Actual Primary Completion Date : August 2015
Actual Study Completion Date : April 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Colonoscopy

Primary Outcome Measures :
  1. Collection of blood and tissue [ Time Frame: Pre-op & during surgery ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   25 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients scheduled for colonoscopy either as routine screening or for a specific problem.


  • Scheduled for colonoscopy as routine screening or for a specific problem


  • Not pregnant


  • No concurrent participation in a clinical trial to treat cancer or prevent cancer recurrence

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00897403

United States, Tennessee
Vanderbilt-Ingram Cancer Center - Cool Springs
Nashville, Tennessee, United States, 37064
Vanderbilt-Ingram Cancer Center at Franklin
Nashville, Tennessee, United States, 37064
Dan Rudy Cancer Center at Saint Thomas Hospital
Nashville, Tennessee, United States, 37205
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States, 37232-6838
Sponsors and Collaborators
Vanderbilt University
National Cancer Institute (NCI)
Study Chair: Daniel C. Liebler, PhD Vanderbilt-Ingram Cancer Center

Responsible Party: Daniel Liebler, Adjunct Professor, Vanderbilt University Medical Center Identifier: NCT00897403     History of Changes
Other Study ID Numbers: CDR0000546530
P30CA068485 ( U.S. NIH Grant/Contract )
First Posted: May 12, 2009    Key Record Dates
Last Update Posted: April 7, 2017
Last Verified: April 2017

Keywords provided by Daniel Liebler, Vanderbilt University Medical Center:
colon cancer
health status unknown

Additional relevant MeSH terms:
Colorectal Neoplasms
Colonic Neoplasms
Intestinal Neoplasms
Gastrointestinal Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Gastrointestinal Diseases
Colonic Diseases
Intestinal Diseases
Rectal Diseases