Improving Lesion Detection in Children With Magnetic Resonance Imaging (MRI)-Negative Partial Epilepsy Using Diffusion Tensor Imaging - Full Text View

Purpose

Focal cortical dysplasia is one of the most common lesions responsible for medically refractory epilepsy in the pediatric population. In patients with medically intractable epilepsy, surgery is the only treatment that will lead to seizure freedom. The outcome of epilepsy surgery is worse in patients when there is no lesion identified on routine structural MRI, also known as MRI-negative partial epilepsy. Diffusion tensor imaging (DTI), a novel MRI technique, can be used to evaluate the integrity of the microstructure of the white matter, even when the white matter appears normal on routine MRI.

Condition	Intervention
Localization-related Epilepsy Partial Epilepsy	Procedure: Diffusion Tensor Imaging (DTI) Procedure: Magnetoencephalography


Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Cross-Sectional
Official Title:	Improving Lesion Detection in Children With MRI-negative Partial Epilepsy Using Diffusion Tensor Imaging

Resource links provided by NLM:

Genetics Home Reference related topics: autosomal dominant partial epilepsy with auditory features pyridoxal 5'-phosphate-dependent epilepsy

MedlinePlus related topics: Diagnostic Imaging Epilepsy

U.S. FDA Resources

Further study details as provided by Elysa Widjaja, The Hospital for Sick Children:

Primary Outcome Measures:

Identify DTI changes in the white matter of children with MRI-negative partial epilepsy and MRI-visible FCD using voxel-by-voxel analysis of FA and MD maps compared to normal controls. [ Time Frame: 1 timepoint; immediately after MRI/DTI ]

Secondary Outcome Measures:

Determine if the lobar location of abnormal FA and MD correlate with the lobar location of MEG defined epileptogenic zone in MRI-negative partial epilepsy and MRI-visible FCD. [ Time Frame: 1 timepoint; immediately after MRI/DTI ]


Enrollment:	64
Study Start Date:	May 2009
Study Completion Date:	May 2012
Primary Completion Date:	May 2012 (Final data collection date for primary outcome measure)

Groups/Cohorts	Assigned Interventions
1 12 children with MRI-negative partial epilepsy who are being worked-up for epilepsy surgery	Procedure: Diffusion Tensor Imaging (DTI) MR and DTI: MRI and DTI will be done using 3.0T Philips MR scanner (Philips Medical Systems, Best, The Netherlands) using an eight channel head coil. DTI and axial 3D T1 will be performed on patients and controls. DTI will be performed using single shot diffusion-weighted echo planar imaging, b=1000s/mm2 and 15 noncollinear directions (TR/TE=10,000/60 ms, slice thickness=2mm, field of view=22cm, matrix=112x112, NEX=2) Axial 3D T1 (TR/TE=4.9/2.3 ms, slice thickness=1 mm, field of view = 24 cm, matrix=220x220, NEX=1) Patients will have additional sequences (axial and coronal T2, proton density and FLAIR) as part of their clinical scan Procedure: Magnetoencephalography MEG will be performed using a whole-head Omega 151-channel gradiometer system (VSM MedTech, Port Coquitalam, BC, Canada). At least 15 2-minute periods of spontaneous data will be recorded with a sampling rate for data acquisition of 625Hz, a bandpass filter of 10 to 70 Hz and a notch filter of 60 Hz. Other Name: MEG
2 12 children with MRI-visible FCD who are being worked-up for epilepsy surgery	Procedure: Diffusion Tensor Imaging (DTI) MR and DTI: MRI and DTI will be done using 3.0T Philips MR scanner (Philips Medical Systems, Best, The Netherlands) using an eight channel head coil. DTI and axial 3D T1 will be performed on patients and controls. DTI will be performed using single shot diffusion-weighted echo planar imaging, b=1000s/mm2 and 15 noncollinear directions (TR/TE=10,000/60 ms, slice thickness=2mm, field of view=22cm, matrix=112x112, NEX=2) Axial 3D T1 (TR/TE=4.9/2.3 ms, slice thickness=1 mm, field of view = 24 cm, matrix=220x220, NEX=1) Patients will have additional sequences (axial and coronal T2, proton density and FLAIR) as part of their clinical scan Procedure: Magnetoencephalography MEG will be performed using a whole-head Omega 151-channel gradiometer system (VSM MedTech, Port Coquitalam, BC, Canada). At least 15 2-minute periods of spontaneous data will be recorded with a sampling rate for data acquisition of 625Hz, a bandpass filter of 10 to 70 Hz and a notch filter of 60 Hz. Other Name: MEG
3 Control Group- Healthy Volunteers	Procedure: Diffusion Tensor Imaging (DTI) MR and DTI: MRI and DTI will be done using 3.0T Philips MR scanner (Philips Medical Systems, Best, The Netherlands) using an eight channel head coil. DTI and axial 3D T1 will be performed on patients and controls. DTI will be performed using single shot diffusion-weighted echo planar imaging, b=1000s/mm2 and 15 noncollinear directions (TR/TE=10,000/60 ms, slice thickness=2mm, field of view=22cm, matrix=112x112, NEX=2) Axial 3D T1 (TR/TE=4.9/2.3 ms, slice thickness=1 mm, field of view = 24 cm, matrix=220x220, NEX=1) Patients will have additional sequences (axial and coronal T2, proton density and FLAIR) as part of their clinical scan

Detailed Description:

The aims of this study are firstly to identify DTI abnormalities in the white matter of children with MRI-negative partial epilepsy and MRI-visible FCD compared to normal controls; and secondly to determine if the location of DTI identified abnormalities correlate with the epileptogenic zone as defined using magnetoencephalography (MEG) dipole clusters. Our hypotheses are firstly DTI can demonstrate the anatomic delineation of white matter abnormalities in MRI-negative partial epilepsy and the alteration in DTI indices are similar in MRI-negative partial epilepsy and MRI-visible FCD, which is the positive control; and secondly the anatomical location of DTI identified abnormalities correlate with the epileptogenic zone as defined by MEG dipole clusters. The long-term goal of this study is to improve detection of subtle lesions in children with MRI-negative partial epilepsy so as to improve the surgical outcome of these patients who undergo epilepsy surgery for seizure control.

Eligibility

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Ages Eligible for Study:	6 Years to 18 Years (Child, Adult)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Patients will be identified from the epilepsy clinic and seizure rounds and who have had previous MRI in an outside institution or prior MRI at least two years ago at the Hospital for Sick Children.

Control children will be recruited through hospital publications and from families participating in the study (healthy siblings)

Criteria

Inclusion Criteria:

MRI negative partial epilepsy group:

Patients diagnosed with partial epilepsy according to the International League Against Epilepsy (ILAE) standard [53]
MRI study reported as normal
Age ranging from 6-18 years (DTI indices alter with myelination and the changes are most marked from birth to 4 years of age)

MRI-visible FCD group:

Patients diagnosed with partial epilepsy according to the ILAE standard [53]
Visual assessment of MRI demonstrates one or more features of FCD
- Cortical thickening
- Alteration in sulci and gyri pattern, including deep sulci
- Blurring of gray-white matter transition
- T2 signal prolongation of the cortex and subcortical white matter
- High T1 signal in the cortex
Age ranging from 6-18 years (DTI indices alter with myelination and the changes are most marked from birth to 4 years of age)

Normal controls:

Subjects with no history of neurological diseases
Age ranging from 6-18 years (most children under the age of 6 years are unable to tolerate the MR examination without general anesthesia or sedation).
No requirement of general anesthesia or sedation

Exclusion Criteria:

Subjects with contraindications for MR imaging (i.e. retained foreign bodies, implants)
Subjects with claustrophobia
Controls with a prior history of traumatic brain injury, neurological disorder, cerebral palsy, developmental delay or learning disability
Controls who require general anesthesia or sedation

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00894478

Locations


Canada, Ontario
The Hospital for Sick Children
Toronto, Ontario, Canada

Sponsors and Collaborators

The Hospital for Sick Children

Investigators


Principal Investigator:	Elysa Widjaja, MD	The Hospital for Sick Children

More Information


Responsible Party:	Elysa Widjaja, Staff Neuroradiologist, The Hospital for Sick Children
ClinicalTrials.gov Identifier:	NCT00894478 History of Changes
Other Study ID Numbers:	1000013137
First Submitted:	May 6, 2009
First Posted:	May 7, 2009
Last Update Posted:	September 10, 2013
Last Verified:	September 2013

Keywords provided by Elysa Widjaja, The Hospital for Sick Children:


MRI-Negative Diffusion tensor imaging Localization-related epilepsy Partial Epilepsy Children

Additional relevant MeSH terms:


Epilepsy Epilepsies, Partial Brain Diseases Central Nervous System Diseases Nervous System Diseases