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Patient's Perception in Symptoms Related to Morning Activity Based on Chronic Obstructive Lung Disease (SYMBOL)

This study has been completed.
Information provided by:
AstraZeneca Identifier:
First received: April 28, 2009
Last updated: December 2, 2010
Last verified: December 2010
The aim of this study is to assess the perception of chronic obstructive pulmonary disease (COPD) patients in symptoms related to morning activities. Also the researchers investigated how to describe the impact of symptoms on sleep quality and how to use the medication in Korea COPD treatments.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective, Observational, Multi-center, Non-interventional Study to Assess Patients Perception in SYmptoms Related to Morning Activity Based on Chronic Obstructive Lung Disease

Resource links provided by NLM:

Further study details as provided by AstraZeneca:

Primary Outcome Measures:
  • To assess the perception of COPD Patients in symptoms related to morning activities [ Time Frame: At baseline and last visit (after 2~3 months) ]

Secondary Outcome Measures:
  • To assess the patient's perception of the variability of symptoms [ Time Frame: At baseline and last visit (after 2~3 months) ]
  • To describe how patients use their COPD treatments [ Time Frame: At baseline and last visit (after 2~3 months) ]
  • To investigate factors that may influence the patient's perception of symptom variability (such as patient characteristics, COPD treatments, co morbidities, etc…) [ Time Frame: At baseline and last visit (after 2~3 months) ]

Estimated Enrollment: 150
Study Start Date: May 2009
Study Completion Date: December 2009
Morning Symptoms (+)
Morning Symptoms (-)


Ages Eligible for Study:   45 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The inclusion/exclusion criteria are designed to select subjects suffering from severe COPD (according to spirometric classification, GOLD stage III and IV) and in a stable state

Inclusion Criteria:

  • COPD outpatients over 45 years old
  • Lung function: post-FEV1 < 50%
  • Current or ex-smoker > 10 packs per year
  • Patients who were not on medication of ISC/FC at least 2 weeks

Exclusion Criteria:

  • Ongoing exacerbation of COPD or within the previous 3 months
  • History of asthma or allergic rhinitis
  • Lung cancer or any other significant respiratory disease such as bronchiectasis, lung fibrosis, interstitial lung disease, tuberculosis, sarcoidosis
  • Current participation in an interventional clinical trial
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00894426

Korea, Republic of
Research Site
Daegu, Korea, Republic of
Research Site
Gyongiju, Korea, Republic of
Research Site
Pohang, Korea, Republic of
Sponsors and Collaborators
Study Director: Joonwoo Bahn Astrazenca Korea, Medical Department
  More Information

Responsible Party: AstraZeneca Identifier: NCT00894426     History of Changes
Other Study ID Numbers: NIS-RKR-DUM-2009/1
Study First Received: April 28, 2009
Last Updated: December 2, 2010

Keywords provided by AstraZeneca:
Morning activity

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases processed this record on May 25, 2017