The Burden and Genetic Variability of Extended-Spectrum ß-Lactamase (ESBL) - Producing Pathogens in Swiss Children
|ClinicalTrials.gov Identifier: NCT00894036|
Recruitment Status : Unknown
Verified May 2009 by University Hospital, Geneva.
Recruitment status was: Recruiting
First Posted : May 6, 2009
Last Update Posted : September 25, 2009
The aim of the study is to determine the molecular epidemiology and genetic variability of ESBL-producing enterobacteriaceae (E-ESBL) among children in Switzerland and to estimate the associated clinical burden of disease.
The investigators' hypotheses are:
- The genetic variability (and especially the distribution of strains harbouring the CTX-M genes) among children is similar to that observed in adults;
- The overall burden of disease is still low in Switzerland compared to neighbouring countries. However, treatment of severe E-ESBL infections is challenging;
- The recommended oral treatment procedure with 3rd generation cephalosporins for febrile urinary tract infection may contribute to increased prevalence of E-ESBL in the long term.
The study is scheduled to start July 1st, 2008, and end June 30th, 2010.
|Condition or disease|
Show Detailed Description
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Observational Model:||Ecologic or Community|
|Official Title:||Epidemiology of Extended-spectrum ß-lactamase (ESBL)-Producing Enteric Gram-negative Bacilli in Swiss Children|
|Study Start Date :||July 2008|
|Estimated Primary Completion Date :||June 2010|
|Estimated Study Completion Date :||December 2010|
- Burden of ESBL-colonization and disease of hospitalized Swiss children [ Time Frame: 2 years ]
- Genetic variability (and especially the distribution of strains harbouring the CTX-M genes) among Swiss children [ Time Frame: 2 years ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00894036
|Contact: Walter Zingg, MDemail@example.com|
|Contact: Christoph Aebi, Proffirstname.lastname@example.org|
|University of Geneva Hospitals||Recruiting|
|Geneva, Switzerland, 1211|
|Contact: Walter Zingg, MD +41223723364 email@example.com|
|Study Chair:||Christoph Aebi, Prof||University Hospital of Berne|