The Burden and Genetic Variability of Extended-Spectrum ß-Lactamase (ESBL) - Producing Pathogens in Swiss Children

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00894036
Recruitment Status : Unknown
Verified May 2009 by University Hospital, Geneva.
Recruitment status was:  Recruiting
First Posted : May 6, 2009
Last Update Posted : September 25, 2009
Information provided by:
University Hospital, Geneva

Brief Summary:


The aim of the study is to determine the molecular epidemiology and genetic variability of ESBL-producing enterobacteriaceae (E-ESBL) among children in Switzerland and to estimate the associated clinical burden of disease.

The investigators' hypotheses are:

  1. The genetic variability (and especially the distribution of strains harbouring the CTX-M genes) among children is similar to that observed in adults;
  2. The overall burden of disease is still low in Switzerland compared to neighbouring countries. However, treatment of severe E-ESBL infections is challenging;
  3. The recommended oral treatment procedure with 3rd generation cephalosporins for febrile urinary tract infection may contribute to increased prevalence of E-ESBL in the long term.

The study is scheduled to start July 1st, 2008, and end June 30th, 2010.

Condition or disease
Enterobacteriaceae Infections

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Ecologic or Community
Time Perspective: Prospective
Official Title: Epidemiology of Extended-spectrum ß-lactamase (ESBL)-Producing Enteric Gram-negative Bacilli in Swiss Children
Study Start Date : July 2008
Estimated Primary Completion Date : June 2010
Estimated Study Completion Date : December 2010

Primary Outcome Measures :
  1. Burden of ESBL-colonization and disease of hospitalized Swiss children [ Time Frame: 2 years ]

Secondary Outcome Measures :
  1. Genetic variability (and especially the distribution of strains harbouring the CTX-M genes) among Swiss children [ Time Frame: 2 years ]

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 15 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All children hospitalized in a pediatric hospital or a pediatric unit in Switzerland

Inclusion Criteria:

  • children who are found being colonized or infected by an ESBL-producing pathogen

Exclusion Criteria:

  • children without ESBL-producing pathogens

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00894036

Contact: Walter Zingg, MD +41223723364
Contact: Christoph Aebi, Prof +41316322111

University of Geneva Hospitals Recruiting
Geneva, Switzerland, 1211
Contact: Walter Zingg, MD    +41223723364   
Sponsors and Collaborators
University Hospital, Geneva
Study Chair: Christoph Aebi, Prof University Hospital of Berne


Responsible Party: Walter Zingg/MD, University of Geneva Hospitals Identifier: NCT00894036     History of Changes
Other Study ID Numbers: MatPed 08-002R
First Posted: May 6, 2009    Key Record Dates
Last Update Posted: September 25, 2009
Last Verified: May 2009

Keywords provided by University Hospital, Geneva:
esbl children Switzerland
ESBL-producing gram-negative bacilli

Additional relevant MeSH terms:
Enterobacteriaceae Infections
Gram-Negative Bacterial Infections
Bacterial Infections