The Burden and Genetic Variability of Extended-Spectrum ß-Lactamase (ESBL) - Producing Pathogens in Swiss Children
Recruitment status was: Recruiting
The aim of the study is to determine the molecular epidemiology and genetic variability of ESBL-producing enterobacteriaceae (E-ESBL) among children in Switzerland and to estimate the associated clinical burden of disease.
The investigators' hypotheses are:
- The genetic variability (and especially the distribution of strains harbouring the CTX-M genes) among children is similar to that observed in adults;
- The overall burden of disease is still low in Switzerland compared to neighbouring countries. However, treatment of severe E-ESBL infections is challenging;
- The recommended oral treatment procedure with 3rd generation cephalosporins for febrile urinary tract infection may contribute to increased prevalence of E-ESBL in the long term.
The study is scheduled to start July 1st, 2008, and end June 30th, 2010.
|Study Design:||Observational Model: Ecologic or Community
Time Perspective: Prospective
|Official Title:||Epidemiology of Extended-spectrum ß-lactamase (ESBL)-Producing Enteric Gram-negative Bacilli in Swiss Children|
- Burden of ESBL-colonization and disease of hospitalized Swiss children [ Time Frame: 2 years ] [ Designated as safety issue: No ]
- Genetic variability (and especially the distribution of strains harbouring the CTX-M genes) among Swiss children [ Time Frame: 2 years ] [ Designated as safety issue: No ]
|Study Start Date:||July 2008|
|Estimated Study Completion Date:||December 2010|
|Estimated Primary Completion Date:||June 2010 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00894036
|University of Geneva Hospitals|
|Geneva, Switzerland, 1211|
|Study Chair:||Christoph Aebi, Prof||University Hospital of Berne|