Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Efficacy of Intramuscular Naloxone 0.4mg. in Prophylaxis of Intrathecal Morphine Induced Pruritus After Cesarean Section

This study has been completed.
Information provided by:
Mahidol University Identifier:
First received: April 26, 2009
Last updated: July 22, 2011
Last verified: July 2011
The purpose of this study is to determine whether intramuscular naloxone 0.4mg. is effective in prophylaxis of intrathecal morphine induced pruritus after cesarean section.

Condition Intervention
Morphine Adverse Reaction
Drug: naloxone
Drug: normal saline

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Efficacy of Intramuscular Naloxone 0.4mg. in Prophylaxis of Intrathecal

Resource links provided by NLM:

Further study details as provided by Mahidol University:

Primary Outcome Measures:
  • efficacy of intrathecal naloxone 0.4mg. in prophylaxis of intrathecal morphine induced pruritus after cesarean section [ Time Frame: 24 hour ]

Enrollment: 60
Study Start Date: May 2009
Study Completion Date: May 2010
Primary Completion Date: October 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: naloxone Drug: naloxone
naloxone 0.4mg.(1 ml) intramuscular
Other Name: narcan
Placebo Comparator: normal saline Drug: normal saline
normal saline 1 ml IM


Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patient schedule for cesarean section ASA class 1

Exclusion Criteria:

  • have contraindication for spinal block
  • complicated pregnancy
  • have history of drug abuse during pregnancy
  • obesity BMI>35kg./m2
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00890942

Anesthesiology department, Siriraj Hospital, Mahidol University
Bangkok, Thailand
Sponsors and Collaborators
Mahidol University
Principal Investigator: Tachawan Jirativanont, MD Anesthesiology department ,Siriraj hopital
  More Information

Responsible Party: Tachawan Jirativanont, Mahidol University Identifier: NCT00890942     History of Changes
Other Study ID Numbers: Si146/2009
Study First Received: April 26, 2009
Last Updated: July 22, 2011

Keywords provided by Mahidol University:
intrathecal morphine

Additional relevant MeSH terms:
Analgesics, Opioid
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Narcotic Antagonists processed this record on May 24, 2017