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Should Any One Airway Clearance Technique be Recommended for People With Cystic Fibrosis? (ACT)

This study has been completed.
Information provided by:
Royal Brompton & Harefield NHS Foundation Trust Identifier:
First received: April 28, 2009
Last updated: NA
Last verified: April 2009
History: No changes posted
The study was to evaluate the long term effects, over one year, of five airway clearance techniques used by people with cystic fibrosis (active cycle of breathing techniques, autogenic drainage, positive expiratory pressure and oscillating positive expiratory pressure (R-C Cornet and Flutter)). The primary outcome measure was forced expiratory volume in one second (FEV1)and the null hypothesis was that there are no differences among the regimens.

Condition Intervention Phase
Cystic Fibrosis Procedure: Airway clearance technique Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Comparison of Five Airway Clearance Techniques in the Treatment of Adults With Cystic Fibrosis

Resource links provided by NLM:

Further study details as provided by Royal Brompton & Harefield NHS Foundation Trust:

Primary Outcome Measures:
  • Forced expiratory volume in one second (FEV1) [ Time Frame: 48 weeks ]

Secondary Outcome Measures:
  • Quality of life (Short Form-36 and Chronic Respiratory Questionnaire) [ Time Frame: 48 weeks ]
  • Exercise capacity (Modified shuttle test) [ Time Frame: 48 weeks ]

Enrollment: 75
Study Start Date: July 1999
Study Completion Date: September 2003
Primary Completion Date: September 2003 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active cycle of breathing techniques
Procedure: Airway clearance technique
Autogenic drainage
Procedure: Airway clearance technique
R-C Cornet
Procedure: Airway clearance technique
Procedure: Airway clearance technique
Procedure: Airway clearance technique


Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosis of cystic fibrosis (genotype or sweat sodium concentration greater than 70 mmol/litre)
  • Forced expiratory volume in one second greater than or equal to 25% predicted, on assessment for entry to the study.

Exclusion Criteria:

  • Evidence of a current respiratory exacerbation (Thornton et al 2004)
  • Current severe haemoptysis
  • Past history of pneumothorax
  • Awaiting lung / heart-lung transplantation
  • Pregnancy
  • Recent (within 3 months) acquisition of Burkholderia cepacia
  Contacts and Locations
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Please refer to this study by its identifier: NCT00890370

Sponsors and Collaborators
Royal Brompton & Harefield NHS Foundation Trust
Principal Investigator: Jennifer A Pryor, PhD Royal Brompton & Harefield NHS Foundation Trust
  More Information

Responsible Party: Dr Jennifer A Pryor, Royal Brompton & Harefield NHS Trust Identifier: NCT00890370     History of Changes
Other Study ID Numbers: 1998CF004B
Study First Received: April 28, 2009
Last Updated: April 28, 2009

Keywords provided by Royal Brompton & Harefield NHS Foundation Trust:
Cystic fibrosis
Airway clearance

Additional relevant MeSH terms:
Cystic Fibrosis
Pathologic Processes
Pancreatic Diseases
Digestive System Diseases
Lung Diseases
Respiratory Tract Diseases
Genetic Diseases, Inborn
Infant, Newborn, Diseases processed this record on September 21, 2017