Brachial Artery Peak Velocity Variation to Predict Fluid Responsiveness
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Brachial Artery Peak Velocity Variation to Predict Fluid Responsiveness in Mechanically Ventilated Patients|
- Predictive value of respiratory variation in brachial artery peak velocity before volume expansion assessed by ROC curve. We defined responser as patients that increased stroke volume index equal or more than 15% after fluid administration. [ Time Frame: immediately after volume expansion ] [ Designated as safety issue: No ]
- Evaluate the predictive value of pulse pressure variation for predicting hemodynamic response to fluid administration, comparing with the predictive value of respiratory variation of brachial artery peak velocity. [ Time Frame: immediately after fluid administration ] [ Designated as safety issue: No ]
- Evaluate the predictive value of stroke volume variation for predicting hemodynamic response to fluid administration, comparing with the predictive value of respiratory variation of brachial artery peak velocity. [ Time Frame: immediately after volume expansion ] [ Designated as safety issue: No ]
|Study Start Date:||December 2008|
|Study Completion Date:||April 2009|
|Primary Completion Date:||March 2009 (Final data collection date for primary outcome measure)|
Acute circulatory failure
Patients for whom the decision to give fluids was taken because the presence of one or more clinical signs of acute circulatory failure.
Other: Fluid administration
500 ml of synthetic colloid (Voluven®, hydroxyethylstarch 6%; Fresenius, Bad Homburg, Germany) infused over 30 minutes
Predicting the hemodynamic response to fluid administration (or fluid responsiveness) in critical ill patients is still a matter of concern, since fluid overload could worse the clinical situation of these patients. Parameters of fluid responsiveness usually require an invasive monitoring (like arterial pulse pressure variation).
We hypothesize that noninvasive evaluation of respiratory variation of peak velocity in brachial artery using Doppler ultrasound could provide a feasible estimation on fluid responsiveness in mechanically ventilated patients with acute circulatory failure.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00890071
|Hospital del SAS de Jerez|
|Jerez de la Frontera, Cádiz, Spain, 11407|
|Principal Investigator:||M. Ignacio Monge García||Hospital del SAS de Jerez|