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Molecular Markers in Cervical Cancer Screening in the Feasibility of the Mathematical Markov Model Analysis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2009 by Wuhan University.
Recruitment status was:  Not yet recruiting
Information provided by:
Wuhan University Identifier:
First received: April 27, 2009
Last updated: NA
Last verified: April 2009
History: No changes posted

The purpose of this study is to:

  1. make p16INK4A as a cervical cancer screening of tumor markers, cytology improve existing diagnostic sensitivity, specificity, repeatability and validity, so as to effectively prompted the early discovery and diagnosis of cervical cancer.
  2. reduce screening costs, screening and benefits into quantitative evaluation, for our country to develop cervical cancer prevention and control strategy to provide a reliable theoretical basis.

Cervical Cancer

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Molecular Markers in Cervical Cancer Screening in the Feasibility of the Mathematical Markov Model Analysis

Resource links provided by NLM:

Further study details as provided by Wuhan University:

Biospecimen Retention:   Samples With DNA
Cervical exfoliated cells

Estimated Enrollment: 200
Study Start Date: April 2009
Estimated Study Completion Date: July 2011
Estimated Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Detailed Description:
  1. To carry out large-scale prospective randomized controlled clinical study to evaluate the "cytological molecular markers Detect + P16INK4A" methods of screening accuracy and reliability, as well as the screening method of the biological effects.
  2. Markov set up mathematical model of screening tests to quantify the inputs and the evaluation proceeds. With a view to optimize and perfect a simple, convenient, practical and efficient program of cervical cancer screening.

Ages Eligible for Study:   25 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
residents of a certain town

Inclusion Criteria:

  • Married women aged 25 to 65-year-old with risk factors
  • No tumor and pelvic radiation therapy history
  • Non-pregnant women at present
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00889902

Contact: Hong B Cai, Doctor 0086-027-67813044
Contact: Ying J Huang

China, Hubei
People'S Hospital
Wufeng county, Hubei, China
Sponsors and Collaborators
Wuhan University
Study Director: Hong B Cai, Doctor gynecologic oncology department, Zhongnan Hospital of Wuhan University
  More Information

Responsible Party: HB Cai, Wuhan University Identifier: NCT00889902     History of Changes
Other Study ID Numbers: 320.6740
Study First Received: April 27, 2009
Last Updated: April 27, 2009

Keywords provided by Wuhan University:
Molecular Markers
Cervical Cancer

Additional relevant MeSH terms:
Uterine Cervical Neoplasms
Uterine Neoplasms
Genital Neoplasms, Female
Urogenital Neoplasms
Neoplasms by Site
Uterine Cervical Diseases
Uterine Diseases
Genital Diseases, Female processed this record on September 21, 2017