The Role of High Resolution-Computed Tomography (CT) in Tuberculosis (TB) Outbreak Investigation

This study has been completed.
Information provided by:
Armed Forces Capital Hospital, Republic of Korea Identifier:
First received: April 28, 2009
Last updated: September 22, 2009
Last verified: September 2009

The aim of this study is to evaluate the role of high-resolution computed tomography of the chest (HRCT) in the investigation of an outbreak of TB that developed in the South Korean army.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Role of Addition of High Resolution-CT in Outbreak Investigation of Tuberculosis

Resource links provided by NLM:

Further study details as provided by Armed Forces Capital Hospital, Republic of Korea:

Enrollment: 92
Study Start Date: December 2007
Study Completion Date: April 2009
Primary Completion Date: January 2009 (Final data collection date for primary outcome measure)
Detailed Description:

Outbreak investigation including tuberculin skin test (TST), QuantiFERON® TB Gold In-Tube (QFT), and simple chest radiography (CXR) will be performed. For participants with any abnormal findings in these tests, HRCT will be carried out. Active pulmonary TB is diagnosed based on sputum studies or HRCT findings. In addition, participants with positive results both in TST and QTF will be treated as having a latent TB infection (LTBI). TST and QTF were repeated in participants with positive result in one of these tests. CXR will be repeated in all participants at 3 and 6 months of follow-up.


Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

A military unit in South Korean Army


Inclusion Criteria:

  • All soldiers who assigned to the military battery where a tuberculosis outbreak occurred

Exclusion Criteria:

  • Soldiers who could not complete study
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Please refer to this study by its identifier: NCT00889759

Sponsors and Collaborators
Armed Forces Capital Hospital, Republic of Korea
Principal Investigator: Jae-Joon Yim, MD Seoul National University Hospital
  More Information

No publications provided

Responsible Party: Sei Won Lee/Division chief of pulmonology, Armed Forces Capital Hospital Identifier: NCT00889759     History of Changes
Other Study ID Numbers: TBoutbreak
Study First Received: April 28, 2009
Last Updated: September 22, 2009
Health Authority: Korea: Food and Drug Administration

Keywords provided by Armed Forces Capital Hospital, Republic of Korea:

Additional relevant MeSH terms:
Actinomycetales Infections
Bacterial Infections
Gram-Positive Bacterial Infections
Mycobacterium Infections processed this record on October 07, 2015