The Role of High Resolution-Computed Tomography (CT) in Tuberculosis (TB) Outbreak Investigation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00889759
Recruitment Status : Completed
First Posted : April 29, 2009
Last Update Posted : September 23, 2009
Information provided by:
Armed Forces Capital Hospital, Republic of Korea

Brief Summary:
The aim of this study is to evaluate the role of high-resolution computed tomography of the chest (HRCT) in the investigation of an outbreak of TB that developed in the South Korean army.

Condition or disease

Detailed Description:
Outbreak investigation including tuberculin skin test (TST), QuantiFERON® TB Gold In-Tube (QFT), and simple chest radiography (CXR) will be performed. For participants with any abnormal findings in these tests, HRCT will be carried out. Active pulmonary TB is diagnosed based on sputum studies or HRCT findings. In addition, participants with positive results both in TST and QTF will be treated as having a latent TB infection (LTBI). TST and QTF were repeated in participants with positive result in one of these tests. CXR will be repeated in all participants at 3 and 6 months of follow-up.

Study Type : Observational
Actual Enrollment : 92 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Role of Addition of High Resolution-CT in Outbreak Investigation of Tuberculosis
Study Start Date : December 2007
Actual Primary Completion Date : January 2009
Actual Study Completion Date : April 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Tuberculosis
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
A military unit in South Korean Army

Inclusion Criteria:

  • All soldiers who assigned to the military battery where a tuberculosis outbreak occurred

Exclusion Criteria:

  • Soldiers who could not complete study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00889759

Sponsors and Collaborators
Armed Forces Capital Hospital, Republic of Korea
Principal Investigator: Jae-Joon Yim, MD Seoul National University Hospital

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Sei Won Lee/Division chief of pulmonology, Armed Forces Capital Hospital Identifier: NCT00889759     History of Changes
Other Study ID Numbers: TBoutbreak
First Posted: April 29, 2009    Key Record Dates
Last Update Posted: September 23, 2009
Last Verified: September 2009

Keywords provided by Armed Forces Capital Hospital, Republic of Korea:

Additional relevant MeSH terms:
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections