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Screening Evaluation for Studies of Chronic Obstructive Pulmonary Disease (COPD)

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ClinicalTrials.gov Identifier: NCT00889447
Recruitment Status : Unknown
Verified April 2013 by Robert A. Wise, Johns Hopkins University.
Recruitment status was:  Active, not recruiting
First Posted : April 29, 2009
Last Update Posted : April 4, 2013
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Robert A. Wise, Johns Hopkins University

Brief Summary:

This research is being done to study mechanisms of progression of COPD and to develop treatments for it. The investigators are doing the present study to identify people age 40 and older with mild to moderate COPD who will qualify for such studies to include in a database. The study will include establishing a screening evaluation or characterization of the following two studies:

  • Emphysema Progression in COPD- Losartan's Effects on Airway Parameters - NA_00009980
  • Sleep-Related Physiology and Inflammation in Chronic Obstructive Pulmonary Disease - NA_00001771

Condition or disease
Chronic Obstructive Pulmonary Disease

Detailed Description:
This is a program to recruit and screen participants for clinical trials or more detailed observational studies of COPD. There are no interventions or comparative results to be published from this study.

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Screening Evaluation for Studies of COPD
Study Start Date : January 2008
Estimated Primary Completion Date : July 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: COPD Lung Diseases
U.S. FDA Resources

Biospecimen Retention:   Samples Without DNA

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Both Male and Female 40 years and older

Inclusion Criteria:

  • Age 40 years and older, either sex
  • Mild to moderate COPD (FEV1/FVC ratio ≤ 0.70, FEV1 30-70% predicted, DLCO ≥35% predicted)
  • On stable maintenance therapy for 2 months
  • Current or former smoker (patient report of at least a 10 pack-year history)
  • Ability to understand and willingness to sign consent documents

Exclusion Criteria:

  • COPD exacerbation requiring treatment within past 6 weeks
  • Untreated arterial hypertension (systolic blood pressure > 140 mm Hg, diastolic blood pressure > 90 mm Hg)
  • Decompensated heart failure
  • Myocardial infarction within past 3 months or ever
  • Evidence of interstitial, occupational or chronic infectious lung disease
  • Renal dysfunction
  • Supplemental oxygen > 2L/m at rest
  • Failure to keep screening appointments

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00889447

United States, Maryland
Johns Hopkins Asthma and Allergy Center
Baltimore, Maryland, United States, 21224
Sponsors and Collaborators
Johns Hopkins University
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Gregory Diette, MD,MHS Johns Hopkins University

Responsible Party: Robert A. Wise, Professor of Medicine, Johns Hopkins University
ClinicalTrials.gov Identifier: NCT00889447     History of Changes
Other Study ID Numbers: NA_00013323
First Posted: April 29, 2009    Key Record Dates
Last Update Posted: April 4, 2013
Last Verified: April 2013

Keywords provided by Robert A. Wise, Johns Hopkins University:
Chronic Obstructive Pulmonary disease (COPD)

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases