This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Screening Evaluation for Studies of Chronic Obstructive Pulmonary Disease (COPD)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2013 by Robert A. Wise, Johns Hopkins University.
Recruitment status was:  Active, not recruiting
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Robert A. Wise, Johns Hopkins University Identifier:
First received: April 27, 2009
Last updated: April 1, 2013
Last verified: April 2013

This research is being done to study mechanisms of progression of COPD and to develop treatments for it. The investigators are doing the present study to identify people age 40 and older with mild to moderate COPD who will qualify for such studies to include in a database. The study will include establishing a screening evaluation or characterization of the following two studies:

  • Emphysema Progression in COPD- Losartan's Effects on Airway Parameters - NA_00009980
  • Sleep-Related Physiology and Inflammation in Chronic Obstructive Pulmonary Disease - NA_00001771

Chronic Obstructive Pulmonary Disease

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: Screening Evaluation for Studies of COPD

Resource links provided by NLM:

Further study details as provided by Robert A. Wise, Johns Hopkins University:

Biospecimen Retention:   Samples Without DNA

Estimated Enrollment: 200
Study Start Date: January 2008
Estimated Primary Completion Date: July 2013 (Final data collection date for primary outcome measure)
Detailed Description:
This is a program to recruit and screen participants for clinical trials or more detailed observational studies of COPD. There are no interventions or comparative results to be published from this study.

Ages Eligible for Study:   40 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Both Male and Female 40 years and older

Inclusion Criteria:

  • Age 40 years and older, either sex
  • Mild to moderate COPD (FEV1/FVC ratio ≤ 0.70, FEV1 30-70% predicted, DLCO ≥35% predicted)
  • On stable maintenance therapy for 2 months
  • Current or former smoker (patient report of at least a 10 pack-year history)
  • Ability to understand and willingness to sign consent documents

Exclusion Criteria:

  • COPD exacerbation requiring treatment within past 6 weeks
  • Untreated arterial hypertension (systolic blood pressure > 140 mm Hg, diastolic blood pressure > 90 mm Hg)
  • Decompensated heart failure
  • Myocardial infarction within past 3 months or ever
  • Evidence of interstitial, occupational or chronic infectious lung disease
  • Renal dysfunction
  • Supplemental oxygen > 2L/m at rest
  • Failure to keep screening appointments
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00889447

United States, Maryland
Johns Hopkins Asthma and Allergy Center
Baltimore, Maryland, United States, 21224
Sponsors and Collaborators
Johns Hopkins University
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Gregory Diette, MD,MHS Johns Hopkins University
  More Information

Responsible Party: Robert A. Wise, Professor of Medicine, Johns Hopkins University Identifier: NCT00889447     History of Changes
Other Study ID Numbers: NA_00013323
Study First Received: April 27, 2009
Last Updated: April 1, 2013

Keywords provided by Robert A. Wise, Johns Hopkins University:
Chronic Obstructive Pulmonary disease (COPD)

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases processed this record on August 18, 2017