Hepatic Mitochondrial Function in Sepsis
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|ClinicalTrials.gov Identifier: NCT00889083|
Recruitment Status : Unknown
Verified June 2011 by Institut d'Anesthesiologie des Alpes Maritimes.
Recruitment status was: Recruiting
First Posted : April 28, 2009
Last Update Posted : July 4, 2011
Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome.
The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Observational Model:||Case Control|
|Official Title:||Evaluation of Hepatic Mitochondrial Function in Sepsis|
|Study Start Date :||April 2009|
|Estimated Primary Completion Date :||April 2012|
|Estimated Study Completion Date :||April 2012|
Non septic patients needing hepatic surgery
Septic patients needing surgery for peritonitis
- Mitochondrial complex activities [ Time Frame: during surgery ]
- Quantification of adenine nucleotides [ Time Frame: during surgery ]
- Quantification of oxidative stress markers [ Time Frame: during surgery ]
- Correlation between SOFA score and mitochondrial complex activities [ Time Frame: 28 days ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00889083
|Contact: Jean-Christophe Orban, MDfirstname.lastname@example.org|
|Contact: Carole Ichai, MD, PhDemail@example.com|
|CHU de Nice||Recruiting|
|Nice, France, 06003|
|Principal Investigator: Jean-Christophe Orban, MD|
|Study Chair:||Carole Ichai, MD, PhD||CHU de Nice|