Oxidative Stress and Cardiac Arrest
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|ClinicalTrials.gov Identifier: NCT00888966|
Recruitment Status : Completed
First Posted : April 28, 2009
Last Update Posted : July 4, 2011
Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy. Recently mild hypothermia has shown a beneficial effect on survival. But the mechanisms underlying these therapy are not clear.
Cardiac arrest is an example of ischemia reperfusion of the entire body. And it is well demonstrated that reperfusion generates an oxidative stress. But it has never been shown in a clinical setting.
The aim of the study is to evaluate oxidative stress after out of hospital cardiac arrest treated with mild hypothermia.
|Condition or disease|
|Study Type :||Observational|
|Estimated Enrollment :||40 participants|
|Official Title:||Evaluation of Oxidative Stress After Out of Hospital Cardiac Arrest Treated With Moderate Hypothermia|
|Study Start Date :||April 2006|
|Actual Primary Completion Date :||June 2010|
|Actual Study Completion Date :||December 2010|
Out of hospital cardiac arrest
Out of hospital cardiac patients successfully resuscitated and admitted to ICU
- Oxidative stress markers and antioxidants after out of hospital cardiac arrest [ Time Frame: 4 days ]
- Lactate after out of hospital cardiac arrest [ Time Frame: 4 days ]
- Outcome after out of hospital cardiac arrest [ Time Frame: 6 months ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00888966
|CHU de Nice|
|Nice, France, 06003|
|Study Chair:||Carole Ichai, MD, PhD||CHU de Nice|