Oxidative Stress and Cardiac Arrest
Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy. Recently mild hypothermia has shown a beneficial effect on survival. But the mechanisms underlying these therapy are not clear.
Cardiac arrest is an example of ischemia reperfusion of the entire body. And it is well demonstrated that reperfusion generates an oxidative stress. But it has never been shown in a clinical setting.
The aim of the study is to evaluate oxidative stress after out of hospital cardiac arrest treated with mild hypothermia.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Evaluation of Oxidative Stress After Out of Hospital Cardiac Arrest Treated With Moderate Hypothermia|
- Oxidative stress markers and antioxidants after out of hospital cardiac arrest [ Time Frame: 4 days ]
- Lactate after out of hospital cardiac arrest [ Time Frame: 4 days ]
- Outcome after out of hospital cardiac arrest [ Time Frame: 6 months ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||April 2006|
|Study Completion Date:||December 2010|
|Primary Completion Date:||June 2010 (Final data collection date for primary outcome measure)|
Out of hospital cardiac arrest
Out of hospital cardiac patients successfully resuscitated and admitted to ICU
Please refer to this study by its ClinicalTrials.gov identifier: NCT00888966
|CHU de Nice|
|Nice, France, 06003|
|Study Chair:||Carole Ichai, MD, PhD||CHU de Nice|