Oxidative Stress and Cardiac Arrest
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ClinicalTrials.gov Identifier: NCT00888966 |
Recruitment Status
:
Completed
First Posted
: April 28, 2009
Last Update Posted
: July 4, 2011
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Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy. Recently mild hypothermia has shown a beneficial effect on survival. But the mechanisms underlying these therapy are not clear.
Cardiac arrest is an example of ischemia reperfusion of the entire body. And it is well demonstrated that reperfusion generates an oxidative stress. But it has never been shown in a clinical setting.
The aim of the study is to evaluate oxidative stress after out of hospital cardiac arrest treated with mild hypothermia.
Condition or disease |
---|
Heart Arrest |
Study Type : | Observational |
Estimated Enrollment : | 40 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Evaluation of Oxidative Stress After Out of Hospital Cardiac Arrest Treated With Moderate Hypothermia |
Study Start Date : | April 2006 |
Actual Primary Completion Date : | June 2010 |
Actual Study Completion Date : | December 2010 |
Group/Cohort |
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Out of hospital cardiac arrest
Out of hospital cardiac patients successfully resuscitated and admitted to ICU
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- Oxidative stress markers and antioxidants after out of hospital cardiac arrest [ Time Frame: 4 days ]
- Lactate after out of hospital cardiac arrest [ Time Frame: 4 days ]
- Outcome after out of hospital cardiac arrest [ Time Frame: 6 months ]
Biospecimen Retention: Samples Without DNA

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Ages Eligible for Study: | 18 Years to 80 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Out of hospital cardiac arrest
Exclusion Criteria:
- refractory shock
- moribund patient
- resuscitation > 60 minutes
- hypothermia < 30 degrees

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00888966
France | |
CHU de Nice | |
Nice, France, 06003 |
Study Chair: | Carole Ichai, MD, PhD | CHU de Nice |
Responsible Party: | Orban MD, CHU de Nice |
ClinicalTrials.gov Identifier: | NCT00888966 History of Changes |
Other Study ID Numbers: |
IAAM 2009-2 |
First Posted: | April 28, 2009 Key Record Dates |
Last Update Posted: | July 4, 2011 |
Last Verified: | June 2011 |
Keywords provided by Institut d'Anesthesiologie des Alpes Maritimes:
heart arrest oxidative stress lactic acid outcome |
Additional relevant MeSH terms:
Heart Arrest Out-of-Hospital Cardiac Arrest Heart Diseases Cardiovascular Diseases |