Prevalence of Renal Artery Stenosis in Patients Referred for Cardiac Catheterization (RAS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00885768
Recruitment Status : Completed
First Posted : April 22, 2009
Results First Posted : March 23, 2010
Last Update Posted : May 13, 2011
Tehran Heart Center
Information provided by:
Imam Khomeini Hospital

Brief Summary:
All patients referred for coronary angiography will simultaneously be evaluated for renal artery stenosis and then stenosis more than 50% will be analyzed according to clinical conditions, risk factors and lab data.

Condition or disease Intervention/treatment
Renal Artery Stenosis Procedure: angiography

Detailed Description:
Renal Artery Stenosis (RAS) is a common finding in patients with generalized atherosclerosis. It is the cause of 15-20% of end stage renal disease in elderly patients. The prevalence of asymptomatic RAS in general population is unknown but it estimated to be 18% in 7th decade and more than 50% in the 8th. It is critical to find and manage the RAS before it's symptoms appear. The Gold standard for diagnosis of atherosclerotic arterial stenosis is angiography. In this study we will evaluate the prevalence, severity, location and related factors to renal artery stenosis in patients whom referred for coronary angiography in period of July-September in one of the most referral heart center in Iran, "The Tehran heart center" which is doing more than 50 coronary angiography daily.

Study Type : Observational
Actual Enrollment : 146 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Prevalence of Renal Artery Stenosis in Patients Refered for Cardiac Catheterization to Heart Center Hospital in July-September 2008
Study Start Date : July 2008
Actual Primary Completion Date : September 2008
Actual Study Completion Date : April 2009

Group/Cohort Intervention/treatment
patients with renal artery stenosis
Procedure: angiography
all patients undergoing coronary angiography with VISIPAQUE and if they had coronary stenosis then renal artery angiography will be done. the dose of contrast will be chosen according to renal function and clinical conditions which will be varied from 75 to 300 ml.

Primary Outcome Measures :
  1. Prevalence of Renal Artery Stenosis (RAS) [ Time Frame: 2 months ]
  2. The Number of Patients With Renal Artery Stenosis [ Time Frame: 3months ]
    the prevalence of renal artery stenosis in patients with coronary artery disease

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All patients reffered to the Tehran Heart center for coronary angiography

Inclusion Criteria:

  • age more than 18 years

Exclusion Criteria:

  • contraindication to contrast use
  • not signing consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00885768

Iran, Islamic Republic of
Tehran Heart Center
Tehran, Iran, Islamic Republic of
Sponsors and Collaborators
Imam Khomeini Hospital
Tehran Heart Center

Responsible Party: Mohammad Reza Khatami, Kidney Research Center Identifier: NCT00885768     History of Changes
Other Study ID Numbers: RAS001
First Posted: April 22, 2009    Key Record Dates
Results First Posted: March 23, 2010
Last Update Posted: May 13, 2011
Last Verified: April 2009

Keywords provided by Imam Khomeini Hospital:
RAS(renal Artery Stenosis)

Additional relevant MeSH terms:
Constriction, Pathologic
Renal Artery Obstruction
Pathological Conditions, Anatomical
Kidney Diseases
Urologic Diseases
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases