QT Variability Pre and Post Cardioversion (DCCV)
The purpose of this study is to learn whether the chemicals in the blood and urine are different when the heart is atrial fibrillation compared to normal sinus rhythm.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||QT Variability Pre & Post Cardioversion in Patient's With Atrial Fibrillation|
- QT variability before and after direct current cardioversion [ Time Frame: 1.5 ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||January 2007|
|Study Completion Date:||March 2012|
|Primary Completion Date:||March 2012 (Final data collection date for primary outcome measure)|
Atrial Fibrillation variably activates the renin-angiotensin-aldosterone system (RAAS), stimulates the sympathetic nervous system, generates oxidant stress, produces natriuretic peptides, and increases ventricular rate. These are interrelated responses and the extent to which these or other pathophysiologic responses determine QT interval during and after Atrial Fibrillation (AF) is unknown. In this study, the QT variability is related to those potential markers in patients with AF undergoing elective DC-cardioversion.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00885391
|United States, Tennessee|
|Vanderbilt University Medical Center|
|Nashville, Tennessee, United States, 37232-0575|
|Principal Investigator:||Dawood Darbar, M.D., Ph.D., F.A.C.C.||Vanderbilt University|