Sidestream Dark-Field (SDF) Imaging of the Intestinal Microcirculation
Sepsis is the most frequent cause of death in critically ill patients in non-coronary care Intensive Care Units in the developed world. Microcirculatory disturbances are central to the development of the disorder, leading to organ dysfunction, multi-organ failure and fatal outcome.
In particular the intestinal microcirculation is impaired early in the course of the disease. This may result in a breakdown of the gut barrier function with translocation of bacteria and their toxins into the systemic circulation, thus sustaining a "gut derived" septic state. Therefore, the impaired intestinal microcirculation has been suggested to act as the "motor of multiple organ failure" in sepsis.
The aim of the project is to evaluate a new diagnostic tool and the impact of Activated Protein C administration on the intestinal microcirculation in patients with severe sepsis and compare the findings with septic patients who are not candidates for APC therapy and healthy patients post bowel surgery using an innovative diagnostic tool (side stream dark-field imaging, SDF).
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Sidestream Dark-Field Imaging of the Intestinal Microcirculation in Clinical Sepsis: The Impact of Activated Protein C Therapy|
- Microvascular Flow Index (MFI) [ Time Frame: 6 hours after treatment ] [ Designated as safety issue: No ]
- Leukocyte - endothelial cell interactions, red blood cell velocity [ Time Frame: 6 hours after treatment ] [ Designated as safety issue: No ]
|Study Start Date:||November 2011|
|Estimated Study Completion Date:||December 2014|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
Patients with ileostomy.
Standard Sepsis Treatment
Patients with ileostomy and sepsis
Please refer to this study by its ClinicalTrials.gov identifier: NCT00883597
|Canada, Nova Scotia|
|Queen Elizabeth II Health Sciences Cetnre|
|Halifax, Nova Scotia, Canada, B3H 2Y9|