Assessment of Colonic Permeability by Confocal Laser Endomicroscopy
Recruitment status was Recruiting
The purpose of this study is to evaluate the efficacy of confocal laser endomicroscopy in assessment of colonic permeability against conventional sugar absorption test.
Inflammatory Bowel Disease
Irritable Bowel Syndrome
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Combined Assessment of Colonic Permeability by Real Time Confocal Laser Endomicroscopy and Sucralose Absorption Test|
- Fluorescein leakage under confocal laser endomicroscopy observation of colonic mucosa. [ Time Frame: Within the 30 minutes after injection of fluorescein ] [ Designated as safety issue: No ]
- Total sucralose excretion. [ Time Frame: Within the 24 hours after drinking of sucralose ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Biopsies during colonoscopy.
|Study Start Date:||April 2009|
|Estimated Study Completion Date:||December 2009|
|Estimated Primary Completion Date:||November 2009 (Final data collection date for primary outcome measure)|
Patients with long standing history or short onset of ulcerative colitis.
Asymptomatic individuals admitted for health surveillance or patients for follow up after polypectomy.
Irritable bowel syndrome
Patients admitted to outpatient department with symptoms meeting ROME III criteria of irritable bowel syndrome.
Increased intestinal permeability has been shown significant in many gastrointestinal diseases, including inflammatory bowel disease and recently irritable bowel syndrome. The conventional test methods of permeability is sugar absorption test which is neither reliable and practical. Confocal laser endomicrosopy is a newly developed device which allows in vivo and real time observation of gastrointestinal mucosa. In our preliminary study we found that the commonly used contrast agent, fluorescein sodium shew differences of leakage into colonic crypt lumen among different patients. The fluorescein leakage might be due to abnormal colonic permeability, so we planed to compare the fluorescein leakage under confocal laser endomicroscopy with conventional sucralose absorption test.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00883077
|Contact: Yanqing Li, PhD. MD.||86-531-8216923 ext firstname.lastname@example.org|
|Department of Gastroenterology, Qilu Hospital, Shandong University||Recruiting|
|Jinan, Shandong, China, 250012|
|Contact: Yanqing Li, PhD. MD. 86-531-82169236 ext 82169508 email@example.com|
|Principal Investigator: Yanqing Li, PhD. MD.|
|Sub-Investigator: Changqing Li, PhD.|
|Study Director:||Yanqing Li, PhD. MD.||Department of Gastroenterology, Qilu Hospital, Shandong University|