Iron & Vitamin C Study
Iron overload is a life-threatening condition that can lead to liver disease, cardiac disease, diabetes and arthritis. Simultaneous supplementation with both iron and AA may place individuals with SCI at risk for iron overload as well as oxidative damage by iron-generated free radicals. Both conditions of high and low iron stores may present with common signs and symptoms. Accurate diagnosis of iron disorder should consider CRP, hematocrit, hemoglobin, serum iron, TIBC, percent saturation of iron binding capacity, serum ferritin and hepcidin.
The investigators are proposing a study to determine the effect of concurrent AA and iron supplementation on iron status of individuals with SCI. The investigators goal is to identify abnormal status that may be attributed to simultaneous supplementation of iron and AA to develop future supplementation protocols in this population for optimal iron status.
Spinal Cord Injury
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Implications of Concurrent Iron and Ascorbic Acid Supplementation on Iron Status in Persons With Spinal Cord Injury|
- To determine iron status if supplemented with ascorbic acid (AA) and/or iron compared to supplementation with iron or AA. [ Time Frame: 1 episode, at least 6 months after consistent ascorbic acid and/or iron supplementation ] [ Designated as safety issue: No ]
- Determine the prevalence of high iron status if receiving supplementation with both iron and AA compared to supplementation with iron or AA. [ Time Frame: 1 episode, at least 6 months after consistent ascorbic acid and/or iron supplementation. ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Blood samples will be obtained for analysis.
|Study Start Date:||June 2008|
|Study Completion Date:||June 2011|
|Primary Completion Date:||December 2010 (Final data collection date for primary outcome measure)|
Ascorbic Acid Supplementation Only
Iron Supplementation Only
Concurrent Ascorbic Acid & Iron Supplementation
Please refer to this study by its ClinicalTrials.gov identifier: NCT00881803
|United States, New York|
|VA Medical Center, Bronx|
|Bronx, New York, United States, 10468|
|Principal Investigator:||William Bauman, MD||VA Medical Center, Bronx|