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Activation of Hepatitis B Virus (HBV) in Hepatitis B Surface Antigen (HBsAg) - Negative But Hepatitis B Core Antibody (Anti-HBc) - Positive Patients

This study has been completed.
Information provided by (Responsible Party):
Yoshihide Ueda, Kyoto University Identifier:
First received: April 13, 2009
Last updated: September 2, 2015
Last verified: September 2015
Individuals with resolved hepatitis B, characterized as hepatitis B surface antigen (HBsAg)-negative and hepatitis B core antibody-positive, have latent hepatitis B virus (HBV) infection in their liver tissue. Cytotoxic chemotherapy and hematopoietic stem cell transplantation sometimes trigger the reactivation of latently infected HBV, resulting in de novo hepatitis B. Although de novo hepatitis B could cause acute liver failure or chronic hepatitis, an effective management strategy for de novo hepatitis B has not been well established. Risk factors and effective management for de novo hepatitis B will be clarified.

Hepatitis B

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Activation of HBV Under Immunosuppression in HBsAg-negative But Anti-HBc-positive Patients With Hematological Malignancies

Resource links provided by NLM:

Further study details as provided by Yoshihide Ueda, Kyoto University:

Enrollment: 33
Study Start Date: August 2006
Study Completion Date: July 2015
Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
HBsAg-negative but anti-HBc-positive patients with hematological malignancies treated at Kyoto University Hospital

Inclusion Criteria:

  • HBsAg-negative but anti-HBc-positive

Exclusion Criteria:

  • Serum HBV DNA-negative
  Contacts and Locations
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Please refer to this study by its identifier: NCT00881036

Kyoto Univesity
Kyoto, Japan, 606-8507
Sponsors and Collaborators
Kyoto University
  More Information

Responsible Party: Yoshihide Ueda, Associate Professor, Kyoto University Identifier: NCT00881036     History of Changes
Other Study ID Numbers: HBV from anti-HBc positive
Study First Received: April 13, 2009
Last Updated: September 2, 2015

Keywords provided by Yoshihide Ueda, Kyoto University:
Hepatitis B

Additional relevant MeSH terms:
Hepatitis A
Hepatitis B
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Hepadnaviridae Infections
DNA Virus Infections processed this record on September 21, 2017