Activation of Hepatitis B Virus (HBV) in Hepatitis B Surface Antigen (HBsAg) - Negative But Hepatitis B Core Antibody (Anti-HBc) - Positive Patients

This study has been completed.
Information provided by (Responsible Party):
Yoshihide Ueda, Kyoto University Identifier:
First received: April 13, 2009
Last updated: September 2, 2015
Last verified: September 2015

Individuals with resolved hepatitis B, characterized as hepatitis B surface antigen (HBsAg)-negative and hepatitis B core antibody-positive, have latent hepatitis B virus (HBV) infection in their liver tissue. Cytotoxic chemotherapy and hematopoietic stem cell transplantation sometimes trigger the reactivation of latently infected HBV, resulting in de novo hepatitis B. Although de novo hepatitis B could cause acute liver failure or chronic hepatitis, an effective management strategy for de novo hepatitis B has not been well established. Risk factors and effective management for de novo hepatitis B will be clarified.

Hepatitis B

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Activation of HBV Under Immunosuppression in HBsAg-negative But Anti-HBc-positive Patients With Hematological Malignancies

Resource links provided by NLM:

Further study details as provided by Kyoto University:

Enrollment: 33
Study Start Date: August 2006
Study Completion Date: July 2015
Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

HBsAg-negative but anti-HBc-positive patients with hematological malignancies treated at Kyoto University Hospital


Inclusion Criteria:

  • HBsAg-negative but anti-HBc-positive

Exclusion Criteria:

  • Serum HBV DNA-negative
  Contacts and Locations
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Please refer to this study by its identifier: NCT00881036

Kyoto Univesity
Kyoto, Japan, 606-8507
Sponsors and Collaborators
Kyoto University
  More Information

No publications provided

Responsible Party: Yoshihide Ueda, Associate Professor, Kyoto University Identifier: NCT00881036     History of Changes
Other Study ID Numbers: HBV from anti-HBc positive
Study First Received: April 13, 2009
Last Updated: September 2, 2015
Health Authority: Japan: Ministry of Education, Culture, Sports, Science and Technology

Keywords provided by Kyoto University:
Hepatitis B

Additional relevant MeSH terms:
Hepatitis A
Hepatitis B
DNA Virus Infections
Digestive System Diseases
Enterovirus Infections
Hepadnaviridae Infections
Hepatitis, Viral, Human
Liver Diseases
Picornaviridae Infections
RNA Virus Infections
Virus Diseases processed this record on October 06, 2015