Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL) (CASL)

This study has been completed.
University of Alabama at Birmingham
Information provided by (Responsible Party):
VA Office of Research and Development Identifier:
First received: April 10, 2009
Last updated: May 15, 2015
Last verified: May 2015
Alzheimer's disease often manifests as a memory disorder before dementia develops. Dementia is considered to be present when a person can no longer handle complex activities of daily living, such as managing finances. This study will investigate the relationship between changes in the ability to manage finances and brain perfusion, which will be measured using continuous arterial spin-labeling (an experimental MRI). Subjects will also undergo neuropsychological tests focusing on several types of memory and thought process, with special emphasis on semantic memory. An important question to be addressed is whether changes in function are better predicted by the neuropsychological tests or by the brain scan.

Alzheimer Disease

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Semantic Memory, Financial Capacity and Brain Perfusion in MCI

Resource links provided by NLM:

Further study details as provided by VA Office of Research and Development:

Primary Outcome Measures:
  • Change in financial capacity (measured with Financial Capacity Instrument) [ Time Frame: 1-5 years ] [ Designated as safety issue: No ]

Biospecimen Retention:   None Retained
N/A- no biospecimens

Estimated Enrollment: 160
Study Start Date: April 2009
Study Completion Date: May 2014
Primary Completion Date: May 2014 (Final data collection date for primary outcome measure)
Arm 1
Elderly patients with non-dementia memory disorder (mild cognitive impairment)
Arm 2
Elderly controls without memory impairment
Arm 3
Patients with mild Alzheimer disease (but preserved routine ADLs)


Ages Eligible for Study:   50 Years to 89 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
160 subjects are anticipated, with the expectation that initial cognitive evaluations will exclude about 60 subjects. We intend to maintain and follow 100 subjects, 40 with non-dementia memory impairment (meeting criteria for amnestic MCI) and 40 with no cognitive impairment, and 20 with mild Alzheimer disease

Inclusion Criteria:

  • Veteran or non-veteran
  • Age 50-89
  • With normal cognition or memory impairment (MCI or mild AD)
  • English speaking
  • Right handed
  • Adequate vision and hearing to take part in tests
  • Able and willing to undergo MRI scan
  • Medically and psychiatrically stable
  • No other brain disease (such as tumor, Parkinson's disease, major stroke)

Exclusion Criteria:

  • Pregnancy
  • Inability to tolerate MRI (due to metal in body or claustrophobia)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00880555

United States, South Carolina
Birmingham VA Medical Center, Birmingham, AL
Birmingham, South Carolina, United States, 35233
Sponsors and Collaborators
VA Office of Research and Development
University of Alabama at Birmingham
Principal Investigator: David G Clark, MD Birmingham VA Medical Center, Birmingham, AL
  More Information

Responsible Party: VA Office of Research and Development Identifier: NCT00880555     History of Changes
Other Study ID Numbers: E6553-W 
Study First Received: April 10, 2009
Last Updated: May 15, 2015
Health Authority: United States: Federal Government

Keywords provided by VA Office of Research and Development:
Magnetic Resonance Imaging
Alzheimer disease
Mild cognitive impairment
Continuous arterial spin labeling
Semantic memory

Additional relevant MeSH terms:
Alzheimer Disease
Mild Cognitive Impairment
Brain Diseases
Central Nervous System Diseases
Cognition Disorders
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Nervous System Diseases
Neurodegenerative Diseases
Tauopathies processed this record on February 11, 2016