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Genetic Factors in Chronic Sinusitis

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ClinicalTrials.gov Identifier: NCT00880516
Recruitment Status : Recruiting
First Posted : April 13, 2009
Last Update Posted : August 26, 2016
Sponsor:
Information provided by (Responsible Party):
University of Chicago

Brief Summary:
The purpose of this study is to learn more about the genetics of chronic sinusitis and identify genes involved in chronic sinusitis.

Condition or disease
Chronic Sinusitis

Study Type : Observational
Estimated Enrollment : 1200 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Genetic Factors in Chronic Sinusitis
Study Start Date : April 2009
Estimated Primary Completion Date : March 2017
Estimated Study Completion Date : March 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sinusitis
U.S. FDA Resources

Group/Cohort
control
Adults with normal sinuses
case
Adults with chronic sinusitis and positive findings on imaging.



Primary Outcome Measures :
  1. Association of genetic variation with CRS disease status [ Time Frame: Adult age ]

Biospecimen Retention:   Samples With DNA
peripheral blood for DNA


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Adults with and without chronic sinusitis
Criteria

Inclusion Criteria:

  • Age> 18 years
  • Diagnosis of chronic sinusitis or normal sinuses (with verification by imaging.) You must have a recent CT scan showing either normal sinuses or the presence of sinus disease.

Exclusion Criteria:

  • Genetic or acquired immunodeficiency
  • Ciliary dyskinesia
  • Cystic fibrosis
  • Autoimmune disease
  • Cancer of the sinuses

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00880516


Contacts
Contact: Marcy deTineo, BSN 773-702-5889 mdetineo@surgery.bsd.uchicago.edu

Locations
United States, Illinois
University of Chicago Recruiting
Chicago, Illinois, United States, 60637
Principal Investigator: Jayant Pinto, MD         
Sponsors and Collaborators
University of Chicago
Investigators
Principal Investigator: Jayant Pinto, MD University of Chicago

Responsible Party: University of Chicago
ClinicalTrials.gov Identifier: NCT00880516     History of Changes
Other Study ID Numbers: 16749A
First Posted: April 13, 2009    Key Record Dates
Last Update Posted: August 26, 2016
Last Verified: August 2016

Additional relevant MeSH terms:
Sinusitis
Chronic Disease
Paranasal Sinus Diseases
Nose Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Disease Attributes
Pathologic Processes