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Theta-burst Transcranial Magnetic Stimulation

This study has been completed.
Information provided by (Responsible Party):
Terence Sanger, University of Southern California Identifier:
First received: March 20, 2009
Last updated: May 28, 2014
Last verified: May 2014
Theta-burst transcranial magnetic stimulation (TBS) is a type of repetitive transcranial magnetic stimulation (rTMS) method that reduces the excitability of a small region of brain for less than one hour. Since dystonia and spasticity may be associated with increased excitability of motor cortex, we expect that by reducing the excitability of motor cortex with TBS we will temporarily improve these symptoms and hopefully open avenues in the future for the use of TBS as a new, non-invasive therapeutic intervention to aid in physical therapy and symptom amelioration of dystonia and spasticity. We will test for motor improvement during the hour immediately following TBS using tests of muscle function and quality of limb movement.

Condition Intervention
Dystonia Device: Transcranial magnetic stimulation

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Theta-burst Transcranial Magnetic Stimulation for the Treatment of Childhood Dystonia and Spasticity

Resource links provided by NLM:

Further study details as provided by Terence Sanger, University of Southern California:

Primary Outcome Measures:
  • surface EMG overflow and control [ Time Frame: 1 hour ]

Enrollment: 5
Study Start Date: January 2008
Study Completion Date: January 2010
Primary Completion Date: January 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Theta-burst Trancranial Magnetic Stim Device: Transcranial magnetic stimulation

  Show Detailed Description


Ages Eligible for Study:   2 Years to 29 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:1. Dystonia affecting one or both hands or arms, and/or spasticity affecting one or both hands/arms 2. Age 2 years to 29 years 3. Sufficient cognitive function to attempt isolated finger movements

Exclusion Criteria:1. any metallic implants in the head or neck 2. seizure within 2 years of study entry, or prior history of status epilepticus outside the newborn period.

3. deep-brain stimulator, vagal nerve stimulator, pacemaker, intrathecal baclofen pump, or other implanted electrical device.

4. prior neurosurgical procedure 5. migraine disorder 6. known cardiac arrhythmia, or history of syncope 7. use of tricyclic antidepressants or neuroleptic medications during the study 8. use or requirement for medications to treat seizures

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00878787

United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
University of Southern California
Principal Investigator: Terence D. Sanger Stanford University
  More Information

Responsible Party: Terence Sanger, Associate Professor, University of Southern California Identifier: NCT00878787     History of Changes
Other Study ID Numbers: SU-03162009-1999
Study First Received: March 20, 2009
Last Updated: May 28, 2014

Additional relevant MeSH terms:
Dystonic Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Movement Disorders
Central Nervous System Diseases processed this record on August 18, 2017