Theta-burst Transcranial Magnetic Stimulation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00878787
Recruitment Status : Completed
First Posted : April 9, 2009
Last Update Posted : May 30, 2014
Information provided by (Responsible Party):
Terence Sanger, University of Southern California

Brief Summary:
Theta-burst transcranial magnetic stimulation (TBS) is a type of repetitive transcranial magnetic stimulation (rTMS) method that reduces the excitability of a small region of brain for less than one hour. Since dystonia and spasticity may be associated with increased excitability of motor cortex, we expect that by reducing the excitability of motor cortex with TBS we will temporarily improve these symptoms and hopefully open avenues in the future for the use of TBS as a new, non-invasive therapeutic intervention to aid in physical therapy and symptom amelioration of dystonia and spasticity. We will test for motor improvement during the hour immediately following TBS using tests of muscle function and quality of limb movement.

Condition or disease Intervention/treatment Phase
Dystonia Device: Transcranial magnetic stimulation Not Applicable

  Show Detailed Description

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 5 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Theta-burst Transcranial Magnetic Stimulation for the Treatment of Childhood Dystonia and Spasticity
Study Start Date : January 2008
Actual Primary Completion Date : January 2010
Actual Study Completion Date : January 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Dystonia

Arm Intervention/treatment
Experimental: Theta-burst Trancranial Magnetic Stim Device: Transcranial magnetic stimulation

Primary Outcome Measures :
  1. surface EMG overflow and control [ Time Frame: 1 hour ]

Information from the National Library of Medicine

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Ages Eligible for Study:   2 Years to 29 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:1. Dystonia affecting one or both hands or arms, and/or spasticity affecting one or both hands/arms 2. Age 2 years to 29 years 3. Sufficient cognitive function to attempt isolated finger movements

Exclusion Criteria:1. any metallic implants in the head or neck 2. seizure within 2 years of study entry, or prior history of status epilepticus outside the newborn period.

3. deep-brain stimulator, vagal nerve stimulator, pacemaker, intrathecal baclofen pump, or other implanted electrical device.

4. prior neurosurgical procedure 5. migraine disorder 6. known cardiac arrhythmia, or history of syncope 7. use of tricyclic antidepressants or neuroleptic medications during the study 8. use or requirement for medications to treat seizures

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00878787

United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
University of Southern California
Principal Investigator: Terence D. Sanger Stanford University

Responsible Party: Terence Sanger, Associate Professor, University of Southern California Identifier: NCT00878787     History of Changes
Other Study ID Numbers: SU-03162009-1999
First Posted: April 9, 2009    Key Record Dates
Last Update Posted: May 30, 2014
Last Verified: May 2014

Additional relevant MeSH terms:
Dystonic Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Movement Disorders
Central Nervous System Diseases