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How Dose Coenzyme Q10 Supplementation During Infertility Treatment Effects Pregnancy Outcome (CoQ10)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00878124
Recruitment Status : Terminated (Very low recruitment rate)
First Posted : April 8, 2009
Last Update Posted : January 12, 2010
Toronto Centre for Advanced Reproductive Technology
Ferring Pharmaceuticals
Information provided by:
University of Toronto

Brief Summary:
As women age the ovarian response and pregnancy rate are reduced while the rate of chromosomal abnormalities in the embryos is increased. Oocyte maturation, accurate chromosomal segregation as well as early embryo development and implantation are dependent on the supply of large amounts of energy, which unlike other cells can only arise from the mitochondria. With age the mitochondria becomes less efficient due to damage to its unique DNA, resulting in decreased energy production. The proposed study will examine the effect of the combination of a dietary supplement, Co enzyme Q10 on pregnancy rate and response of the ovaries to a medication that stimulates follicle growth. The investigators hypothesize that the improved energetic state of the oocyte would result in a more accurate chromosomal separation, increased embryo quality and pregnancy rate.

Condition or disease Intervention/treatment Phase
Poor Ovarian Response Dietary Supplement: Coenzyme Q10 co treatment Other: Placebo Caps Not Applicable

Detailed Description:

The study will be organized on an outpatient basis at the Toronto Centre for Advanced Reproductive Technology (TCART) and at the Lifequest Centre for Reproductive Medicine. The study will involve 100 women aged 38-43 years.

In the first cycle, study participants will be randomly assigned to either placebo or COQ10 capsules, (AOR - Advanced Orthomolecular Research Inc. 19 St NE Calgary, Alberta, NHPD registration codes 135307 and 113519, respectively). Study participants will take 600 mg of CoQ10 orally or identical placebo capsules for up to 5 cycles if pregnancy does not occur. All subjects will commence controlled ovarian stimulation (COH) using highly purified human menopausal gonadotropins (Menopur; Ferring Inc., North York,Ontario Canada). The starting dosage of Menopur will range from 75IU to 250 IU daily S.C. will be determined by the physician and will begin on the third day of menses, and will continue until the day prior to human chorionic gonadotropin (hCG) administration. The dosage will not be changed and must be maintained for the duration of the study. Menopur will continue daily until follicular development is considered adequate. (at least 1 follicle is >17 mm, and the E2 level is acceptable for the number of follicles present). The patient will receive an injection of hCG 250 mcg (Ovidrel, EMD Serono,Oakville, Ontario, Canada ), SC for the final stage of follicular maturation. Insemination will be by intrauterine insemination (IUI). Luteal support will consist of progesterone suppositiories 200mg (Kingsway Pharmacy,Toronto, Ontario Canada) vaginally per day starting on the day of IUI and will continue for 2 weeks until the serum beta hCG result. At the end of each cycle serum beta hCG will be drawn and if women are pregnant CoQ10/ placebo will be discontinued. If pregnant, luteal support will continue until 10 weeks gestation. If the patient is not pregnant she will have a cycle off COH but may attempt to conceive naturally. In the third cycle, COH using the same dose of Menopur as in the first cycle will be performed with IUI as in cycle one. If not pregnant, another cycle off treatment will be followed by the fifth cycle in which COH and IUI is performed..

The study endpoints will be:

  1. Primary outcome measure will be pregnancy rate.
  2. Secondary outcome measures will include:

    • Peak estradiol level
    • The number of follicles > 14 mm on day of hCG
    • Number of days of stimulation / units of Menopur needed

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Prevention
Official Title: The Influence of Concomitant Co Enzyme Q10 Use on Pregnancy Outcome in Intrauterine Insemination
Study Start Date : June 2009

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: CoQ10
Coenzyme Q10 co-treatment
Dietary Supplement: Coenzyme Q10 co treatment
CoenzymeQ10 300mg twice a day continuously. Ceased when patient conceives or at the end of the study.
Other Name: Ubiquinone.

Placebo Comparator: Placebo control
Placebo Co-treatment
Other: Placebo Caps
3 caps twice a day continuously until pregnant or at the end of the study.

Primary Outcome Measures :
  1. Pregnancy rate [ Time Frame: Every cycle ]

Secondary Outcome Measures :
  1. Peak estradiol level [ Time Frame: Every cycle ]
  2. The number of follicles > 14 mm on day of hCG [ Time Frame: Every cycle ]
  3. Number of days of stimulation/units of Menopur needed [ Time Frame: Every cycle ]

Information from the National Library of Medicine

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Ages Eligible for Study:   38 Years to 43 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Each patient must meet the following criteria:
  • Age 38-43 years at the time of enrollment
  • Diagnosis of primary infertility

Exclusion Criteria:

  • Patients must NOT have any of the following:
  • Body mass index (BMI) > 38 kg/m2
  • Early follicular phase (day 2-4) serum FSH level > 20 mIU/ml.
  • Abnormal uterine cavity and /or tubal blockage as evidenced by sonohysterogram or hysterosalpingography
  • Any current use of systemic steroid medication within 3 months of study enrollment.
  • Any contraindication to being pregnant and carrying a pregnancy to term.
  • Contraindication for the use of CoQ10, Menopur, hCG, and Prometrium.
  • Any ovarian or abdominal abnormality that may interfere with adequate TVS evaluation.
  • Absence of one ovary
  • Clinically relevant systemic disease (e.g., Insulin-dependent diabetes, adrenal dysfunction, organic intracranial lesion, hyperprolactinemia, or hypothalamic tumor) or serious illness (Neoplasia).
  • History (within past 12 months) or current abuse of alcohol or drugs.
  • Administration of any investigational drugs within three months prior to study enrollment.
  • Any medical condition that may interfere with the absorption, distribution, metabolism or excretion of the study drugs, gastrointestinal diseases, mal absorption syndromes and liver dysfunction
  • Unexplained gynecological bleeding.
  • Abnormal sperm quality or semen sample inadequate for IUI preparation (TMC > 1x106 post wash)
  • Patient not able to communicate adequately with the investigators and to comply with the requirements of the entire study.
  • Abnormal COH screening bloods for either partner, including: HIV serology, Hepatitis B and C serology, Rubella, and syphilis serology prior to participation in study.
  • Unwillingness to give written informed consent.
  • The concurrent use of any of the following drugs:
  • CoQ10: Daunorubicin, Doxorubicin, Blood Pressure Medications, Warfarin, Timolol, atorvastatin, cerivastatin, lovastatin, pravastatin, simvastatin gemfibrozil, tricyclic antidepressant medications (including amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, and trimipramine).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00878124

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Canada, Ontario
LifeQuest Centre for Reproductive Medicine
Toronto, Ontario, Canada, M5G 2K4
Toronto center for advanced reprodutive technology
Toronto, Ontario, Canada, M5S 2X9
Sponsors and Collaborators
University of Toronto
Toronto Centre for Advanced Reproductive Technology
Ferring Pharmaceuticals
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Principal Investigator: Robert F Casper, Prof University of Toronto
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Responsible Party: Dr. Yaakov Bentov, University of Toronto Identifier: NCT00878124    
Other Study ID Numbers: CoQ10 - 08-0205-A
First Posted: April 8, 2009    Key Record Dates
Last Update Posted: January 12, 2010
Last Verified: January 2010
Keywords provided by University of Toronto:
Poor ovarian response
Chromosomal aberrations
poor pregnancy outcome
Late maternal age
Additional relevant MeSH terms:
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Coenzyme Q10
Growth Substances
Physiological Effects of Drugs