Trial record 18 of 134 for:
Sex Differences in Early Brain Development; Brain Development in Turner Syndrome
This study has been completed.
First Posted: April 8, 2009
Last Update Posted: May 2, 2014
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National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Rebecca Knickmeyer Santelli, University of North Carolina, Chapel Hill
Relative risk for many psychiatric disorders differs dramatically in males and females. Early-onset disorders, such as autism, occur more often in males; other conditions, such as schizophrenia, occur at similar rates in males and females, but the sexes differ in expression. It has been hypothesized that the prevalence and expression of these disorders is related to sex differences in brain development. X-chromosome effects and early exposure to gonadal hormones are strong candidates for a causal role. The aims of the research are (1) to characterize sex differences in brain development from birth to age 2; (2) to test whether brain development is altered in infants with Turner syndrome, a well-defined genetic disorder resulting from the partial or complete loss of one of the sex chromosomes. To address aim 1, high resolution MRI, including diffusion tensor imaging (DTI), will be used to characterize sex differences in brain development from birth to age 2 in a longitudinal cohort of 250 children. To address aim 2, high resolution MRI, including DTI, will be used to compare brain development in 70 infants with Turner syndrome (X monosomy) to matched controls from aim 1. The investigators hypothesize that sex differences in gray and white matter development and in white matter maturation as assessed by DTI will be present during the first 2 years of life and that children with TS will exhibit abnormal gray and white matter development in the neonatal period.
||Observational Model: Case Control
Time Perspective: Prospective
||Sex Differences in Early Brain Development; Brain Development in Turner Syndrome
Primary Outcome Measures:
- Brain volumes on MRI [ Time Frame: 2-4 weeks post birth ]
Biospecimen Retention: Samples With DNA
Secondary Outcome Measures:
- Brain volumes and DTI parameters [ Time Frame: 2-4 weeks post birth, 1 yr, 2 yr ]
For participating children with Turner Syndrome, subjects may participate in an optional blood draw for DNA extraction and hormone assays.
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||May 2014 (Final data collection date for primary outcome measure)
Typically developing children drawn from the general population
Children with Turner Syndrome