Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial

This study has been completed.
Information provided by (Responsible Party):
Sylvie Petitjean, University Hospital, Basel, Switzerland Identifier:
First received: April 6, 2009
Last updated: January 28, 2015
Last verified: January 2015
The purpose of this study is to determine whether prize-based contingency management (prizeCM) combined with cognitive behavioral therapy (CBT) is more effective in the treatment of of cocaine-dependent patients compared to CBT only. Patients were randomized to prizeCM + CBT (experimental group) or to CBT (control group) an treated over 24 weeks. It is the first trial of this type in Europe.

Condition Intervention
Cocaine-related Disorders
Behavioral: Cognitive behavioral therapy (CBT)

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial

Further study details as provided by University Hospital, Basel, Switzerland:

Primary Outcome Measures:
  • retention in treatment, cocaine abstinence [ Time Frame: 24 weeks ] [ Designated as safety issue: No ]
    cocaine abstinence: at least 3 consecutive weeks of cocaine abstinence, the maximum number of weeks of continous abstinence and proportions of cocaine-free urine samples during the entire 24-week and at 6-month follow-up.

Secondary Outcome Measures:
  • patients' satisfaction with the therapy, clinical measures [ Time Frame: 24 weeks ] [ Designated as safety issue: No ]
    patients' satisfaction with prize-based contingency management and with CBT

Enrollment: 60
Study Start Date: September 2008
Study Completion Date: October 2014
Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Cognitive behavioral therapy (CBT) + prize-based contingency management (prizeCM)
Behavioral: Cognitive behavioral therapy (CBT)
Active Comparator: 2
Cognitive behavioral therapy (CBT)
Behavioral: Cognitive behavioral therapy (CBT)


Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • cocaine dependence, aged 18 or older, other dependences

Exclusion Criteria:

  • severe somatic, brain, or psychiatric disease, attention deficit disorders with medication methylphenidate
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Please refer to this study by its identifier: NCT00877435

Universitäre Psychiatrischen Kliniken
Basel, Switzerland, 4025
Fondation Phenix
Geneva, Switzerland, 1221
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Principal Investigator: Sylvie A Petitjean, Dr. phil. Psychiatric Hospital of the University of Basel
  More Information

Additional Information:
No publications provided

Responsible Party: Sylvie Petitjean, Dr. phil, University Hospital, Basel, Switzerland Identifier: NCT00877435     History of Changes
Other Study ID Numbers: SNF-105314-120675 
Study First Received: April 6, 2009
Last Updated: January 28, 2015
Health Authority: Switzerland: Ethikkommission

Additional relevant MeSH terms:
Cocaine-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Substance-Related Disorders processed this record on February 04, 2016