Vitamin D Supplementation Prevents Elderly Pneumonia
Pneumonia is the fourth leading cause of death and frequently occurs in institutionalized elderly people in Japan. Recently, several clinical and experimental studies have reported the importance of vitamin D in the regulation of immune functions and its deficiency is associated with susceptibility to some infections. In the present study, the investigators hypothesize that deficiency of serum vitamin D is associated with development of pneumonia, and supplementation of vitamin D may lower the incidence of pneumonia and prolong survival in institutionalized elderly subjects.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Prevention
|Official Title:||Vitamin D Supplementation Prevents Pneumonia in Institutionalized Elderly Subjects|
- prevalence of pneumonia [ Time Frame: one year ] [ Designated as safety issue: Yes ]
- all cause mortality [ Time Frame: one year ] [ Designated as safety issue: Yes ]
|Study Start Date:||August 2008|
No Intervention: Group A
Group A is identified as serum vitamin D level more than 16 ng/dl.
Active Comparator: Group B
Group B is identified as serum vitamin D level less than 16 ng/dl and is supplemented with vitamin D3.
Dietary Supplement: Vitamin D3
Group A and Group C are followed without drugs and Group B is followed with vitamin D3.
No Intervention: Group C
Group C is identified as serum vitamin D less than 16 ng/dl and is not supplemented with vitamin D3.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00877422
|Institute of Development, Aging and Cancer, Tohoku University|
|1-1,Seiryo-machi,Aoba-ku,Sendai, Japan, 980-8575|
|Study Chair:||Hiroyuki Arai, MD||Department of Geriatrics and Gerontology, Tohoku University|