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The Health Benefits of Conjugated Linoleic Acid (CLA) for Asthma & Allergy

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ClinicalTrials.gov Identifier: NCT00876356
Recruitment Status : Completed
First Posted : April 6, 2009
Last Update Posted : April 6, 2009
Sponsor:
Collaborators:
Canadian Institutes of Health Research (CIHR)
Canadian Lung Association/British Columbia Lung Association
Natural Inc./Cognis GmbH (Dusseldorf, Germany)
Information provided by:
University of British Columbia

Brief Summary:
Conjugated linoleic acids (CLA) are naturally occurring free fatty acids derived from the tissues and milk of ruminant animals such as cows. CLA has multiple biological properties including regulation of metabolism and immune processes, including tissue inflammation. Asthma symptoms are caused by irritation and inflammation of the airways. Our hypothesis was that CLA may reduce airway inflammation in asthma and thus reduce asthma symptoms. The aim of this pilot study was to investigate the efficacy and safety of CLA as a dietary supplement in mild asthma. Subjects will be assigned to take CLA dietary supplements or placebo (olive oil) for 12 weeks in addition to their usual asthma treatment. They will be monitored for asthma symptoms, side effects, lung function and blood markers of inflammation.

Condition or disease Intervention/treatment Phase
Asthma Dietary Supplement: Conjugated Linoleic Acid (CLA) Dietary Supplement: Olive oil Not Applicable

  Show Detailed Description

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: Conjugated Linoleic Acid (CLA) as Adjunctive Therapy in Mild Asthmatics: A Pilot Study.
Study Start Date : May 2002
Actual Primary Completion Date : May 2002
Actual Study Completion Date : September 2004

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma
U.S. FDA Resources

Arm Intervention/treatment
Active Comparator: 1
Conjugated Linoleic Acid 4.5g/day in three divided doses p.o. for 12 weeks
Dietary Supplement: Conjugated Linoleic Acid (CLA)
CLA 4.5g/day in three divided doses p.o. for 12 weeks
Placebo Comparator: 2
Olive oil 4.5g/day x 12 weeks.
Dietary Supplement: Olive oil
Olive oil 4.5g/day x 12 weeks



Primary Outcome Measures :
  1. PC20 - methacholine sensitivity [ Time Frame: 12 weeks ]

Secondary Outcome Measures :
  1. Quality of life (QoL), body mass index (BMI), systemic cytokine levels, and adverse events. [ Time Frame: 12 weeks ]


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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Mild asthma - FEV1 > 70% predicted Positive methacholine challenge

Exclusion Criteria:


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00876356


Locations
Canada, British Columbia
St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Sponsors and Collaborators
University of British Columbia
Canadian Institutes of Health Research (CIHR)
Canadian Lung Association/British Columbia Lung Association
Natural Inc./Cognis GmbH (Dusseldorf, Germany)
Investigators
Principal Investigator: Delbert Dorscheid, MD, Ph.D University of British Columbia
Study Director: Ruth MacRedmond, MD, FRCPC University of British Columbia

Responsible Party: Dr. Delbert R. Dorscheid, University of British Columbia
ClinicalTrials.gov Identifier: NCT00876356     History of Changes
Other Study ID Numbers: P01-0180
First Posted: April 6, 2009    Key Record Dates
Last Update Posted: April 6, 2009
Last Verified: April 2009

Keywords provided by University of British Columbia:
Asthma
Conjugated Linoleic Acid (CLA)
dietary supplement

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases