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Magnetically Navigated vs. Manually Guided Radiofrequency in Atrioventricular-node-reentry-tachycardia (MAGMA-AVNRT)

This study has been completed.
University of Bergen
Information provided by:
Deutsches Herzzentrum Muenchen Identifier:
First received: April 3, 2009
Last updated: June 24, 2016
Last verified: June 2016
The MAGMA-AVNRT study compares two different methods of handling the ablation catheters for av-node-reentry-tachycardia with regard to x-ray dose, safety and success: manually guided vs magnetically navigated RF-catheter.

Condition Intervention Phase
Atrioventricular Nodal Reentry Tachycardia Radiofrequency Ablation Procedure: RF-ablation Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Randomized Comparison Between Magnetically Navigated vs Manually Guided Radiofrequency in AV-node-reentry-tachycardia

Further study details as provided by Deutsches Herzzentrum Muenchen:

Primary Outcome Measures:
  • Total x-ray time and dose for patient [ Time Frame: electrophysiological examination ]

Secondary Outcome Measures:
  • X-ray time and dose for physician [ Time Frame: electrophysiological study ]
  • Safety of ablation (AV-Block, perforation) [ Time Frame: end of electrophysiological study ]
  • short-term and long-term-success [ Time Frame: end of procedure and 6 months after procedure ]
  • number of RF-application [ Time Frame: procedure ]
  • Duration of electrophysiological study (ablation included) [ Time Frame: procedure ]

Estimated Enrollment: 300
Study Start Date: April 2009
Study Completion Date: October 2012
Primary Completion Date: March 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Manually guided
Treatment with manually guided RF-catheter
Procedure: RF-ablation
4mm-tip catheter manually guided vs magneticallly navigated
Experimental: Magnetically navigated
Treatment with magnetically navigated RF-catheter.
Procedure: RF-ablation
4mm-tip catheter manually guided vs magneticallly navigated

Detailed Description:

AV-node reentry tachycardia can be treated by radiofrequency ablation or modulation of the slow pathway of the av node. The success rate is 90 to 95%.

There are different options to navigate the ablation catheter: manually guided vs magnetically guided.

For magnetic guidance two magnets are positioned beneath the patient. A mangetic field is induced and a catheter with a ferromagnetic tip can be navigated from outside with a joystick by modifying the vectors of the magnetic field.

We hypothesized that a magnetic guidance of the RF-ablation catheter results in lower x-ray time and dose for the patient and the physician with comparable safety und success rates.


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 18 to 70 years old
  • suspected AV-node-reentry-tachycardia
  • written informed consent

Exclusion Criteria:

  • pregnancy
  • contraindication against electrophysiological study or ablation
  • congenital heart disease or other anatomical abnormalities
  • previous surgical procedure involving atrium except aorto-coronary bypass grafts
  • psychiatric disease that makes a completion of study improbable
  • severe comorbidities with a life expectancy less than 6 months
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Please refer to this study by its identifier: NCT00875914

University Hospital Bergen
Bergen, Norway, 5021
Sponsors and Collaborators
Deutsches Herzzentrum Muenchen
University of Bergen
Study Chair: Gabi Hessling, MD Deutsches Herzzentrum München
Study Chair: Peter Schuster, MD University of Bergen
Study Chair: Isabel Deisenhofer, MD Deutsches Herzzentrum München
  More Information

Responsible Party: Gabi Hessling MD, Deutsches Herzzentrum Muenchen Identifier: NCT00875914     History of Changes
Other Study ID Numbers: GE IDE No. C00909
Study First Received: April 3, 2009
Last Updated: June 24, 2016

Keywords provided by Deutsches Herzzentrum Muenchen:
AV-node reentry tachycardia
radiofrequency ablation
magnetic navigation system

Additional relevant MeSH terms:
Tachycardia, Atrioventricular Nodal Reentry
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Tachycardia, Reciprocating processed this record on September 21, 2017