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Effect of Rosuvastatin Response in Healthy Subjects: Potential Mechanisms of Anti-inflammatory Effects

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ClinicalTrials.gov Identifier: NCT00874757
Recruitment Status : Unknown
Verified August 2011 by University of Nebraska.
Recruitment status was:  Recruiting
First Posted : April 2, 2009
Last Update Posted : August 3, 2011
Sponsor:
Information provided by:
University of Nebraska

Brief Summary:
The purpose of this study is to see whether Statin drugs will act as anti-inflammatories. The investigators will study this potential anti-inflammatory activity in healthy subjects.

Condition or disease
Healthy

Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effect of Rosuvastatin Response in Healthy Subjects: Potential Mechanisms of
Study Start Date : July 2009
Estimated Primary Completion Date : December 2011
Estimated Study Completion Date : December 2011

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Ages Eligible for Study:   19 Years to 39 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
20 healthy subjects
Criteria

Inclusion Criteria:

  • Healthy male non-asian subjects

Exclusion Criteria:

  • Patients with increased liver function tests, elevated serum creatinine, patients on anti-inflammatory or immunomodulating drugs

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00874757


Contacts
Contact: Timothy R McGuire, Pharm.D. 402-559-8224 trmcguir@unmc.edu
Contact: Paul Dobesh, Pharm.D. 402-559-1983 pdobesh@unmc.edu

Locations
United States, Nebraska
UNMC College of Pharmacy Recruiting
Omaha, Nebraska, United States, 68198-6045
Contact: Timothy R McGuire, Pharm.D.    402-559-8224    trmcguir@unmc.edu   
Contact: Paul Dobesh, Pharm.D.    402-559-1983    pdobesh@unmc.edu   
Sponsors and Collaborators
University of Nebraska
Investigators
Principal Investigator: Timothy R McGuire, PharmD University of Nebraska

Responsible Party: Timothy R. McGuire, University of Nebraska College of Pharmacy
ClinicalTrials.gov Identifier: NCT00874757     History of Changes
Other Study ID Numbers: 088-09
First Posted: April 2, 2009    Key Record Dates
Last Update Posted: August 3, 2011
Last Verified: August 2011

Keywords provided by University of Nebraska:
Statins, anti-inflammatory
Healthy subjects study

Additional relevant MeSH terms:
Rosuvastatin Calcium
Anti-Inflammatory Agents
Anticholesteremic Agents
Hypolipidemic Agents
Antimetabolites
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Enzyme Inhibitors