Effect of Rosuvastatin Response in Healthy Subjects: Potential Mechanisms of Anti-inflammatory Effects

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2011 by University of Nebraska.
Recruitment status was:  Recruiting
Information provided by:
University of Nebraska
ClinicalTrials.gov Identifier:
First received: April 1, 2009
Last updated: August 2, 2011
Last verified: August 2011
The purpose of this study is to see whether Statin drugs will act as anti-inflammatories. The investigators will study this potential anti-inflammatory activity in healthy subjects.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effect of Rosuvastatin Response in Healthy Subjects: Potential Mechanisms of

Resource links provided by NLM:

Further study details as provided by University of Nebraska:

Estimated Enrollment: 20
Study Start Date: July 2009
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   19 Years to 39 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
20 healthy subjects

Inclusion Criteria:

  • Healthy male non-asian subjects

Exclusion Criteria:

  • Patients with increased liver function tests, elevated serum creatinine, patients on anti-inflammatory or immunomodulating drugs
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00874757

United States, Nebraska
UNMC College of Pharmacy
Omaha, Nebraska, United States, 68198-6045
Sponsors and Collaborators
University of Nebraska
Principal Investigator: Timothy R McGuire, PharmD University of Nebraska
  More Information

Responsible Party: Timothy R. McGuire, University of Nebraska College of Pharmacy
ClinicalTrials.gov Identifier: NCT00874757     History of Changes
Other Study ID Numbers: 088-09 
Study First Received: April 1, 2009
Last Updated: August 2, 2011

Keywords provided by University of Nebraska:
Statins, anti-inflammatory
Healthy subjects study

Additional relevant MeSH terms:
Rosuvastatin Calcium
Anti-Inflammatory Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Anticholesteremic Agents
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Enzyme Inhibitors
Lipid Regulating Agents

ClinicalTrials.gov processed this record on January 19, 2017