Microbiology and Clinical Outcome of Pneumonia
|ClinicalTrials.gov Identifier: NCT00873522|
Recruitment Status : Unknown
Verified March 2009 by Taichung Veterans General Hospital.
Recruitment status was: Recruiting
First Posted : April 1, 2009
Last Update Posted : April 1, 2009
Pneumonia occurring outside of the hospital setting is regarded as community acquired pneumonia. However, pneumonia occurring in non-hospital long-term care facilities constituted a distinct type of pneumonia from CAP. Kollef et al has justified health care associated pneumonia (HCAP) as a new category of pneumonia . The HCAP patients are associated with severe disease, higher mortality rate, and greater length of stay and increased cost . HCAP are often at risk for multi-drug resistant bacterial pathogens such as Pseudomonas aeruginosa, extended-spectrum beta-lactamase Klebsiella pneumoniae, Acinetobacter baumannii, and methicillin-resistant S. aureus (MRSA) .
Health care facilities have not been defined in Taiwan. Respiratory care ward (RCW) is a special unit to take care long-term ventilatory dependent patients in Taiwan. Some of the patients get pneumonia and are referred back to medical centers. Besides, community-acquired P. aeruginosa, Acinetobacter baumannii or MRSA have been reported [3-8]. Therefore, the core-organisms of HCAP in Taiwan might be multi-drug resistant and the causes of inadequate initial antibiotics treatment. The common pathogens were also unknown.
Till now, there are no data about the pathogens of HCAP in Taiwan. We define the health-care facilities and initiate a retrospective study to characterize the microbiology and clinical outcome of Community acquired pneumonia and Health-Care-Associated pneumonia in Taiwan. Further analysis will perform to confirm the differences between CAP an HCAP in Taiwan.
I. To characterize CAP and HCAP i. Microbiological epidemiology ii. Disease severity: PSI iii. Outcome : length of stay, mortality , antimicrobial susceptibility and treatment outcomes II. To characterize HCAP from RCW i. Microbiological epidemiology ii. Disease severity: PSI iii. Outcome : length of stay, mortality
- Study design:
This is a retrospective multi-center cohort study to characterize microbiology, and clinical outcomes in Taiwan.
Data sources: CAP or HCAP registered in 4 medical centers from Jan 1 2007 to Dec. 31 2007. (2 in north Taiwan, 1 in central Taiwan, 1 in south Taiwan) Expected case number: 800 HCAP and 1800 CAP
|Condition or disease|
Show Detailed Description
|Study Type :||Observational|
|Estimated Enrollment :||2600 participants|
|Official Title:||Microbiology and Clinical Outcome of Community Acquired Pneumonia and Health-Care-Associated Pneumonia in Taiwan: a Multi-Center Study|
|Study Start Date :||March 2008|
|Estimated Primary Completion Date :||March 2010|
|Estimated Study Completion Date :||March 2010|
|Community acquired pneumonia|
- Success/favorable clinical response after treatment for pneumonia [ Time Frame: weeks ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00873522
|Contact: Chieh-Liang Wu, MD||+886-4-23592525 ext email@example.com|
|Taichung Veterans General Hospital||Recruiting|
|Taichung City, Taiwan, 40705|
|Contact: Chieh-Liang Wu, MD +886-4-23592525 ext 3370 firstname.lastname@example.org|
|Principal Investigator: Chieh-Liang Wu, MD|
|Principal Investigator:||Chieh-Liang Wu, MD||Department of Respiratory Therapy, Taichung Veterans General Hospital|