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Transcranial Direct Current Stimulation (tDCS) and Hallucinations in Schizophrenia

This study has been completed.
Information provided by (Responsible Party):
Hôpital le Vinatier Identifier:
First received: March 26, 2009
Last updated: February 28, 2017
Last verified: February 2017
The purpose of this study is to determine whether trans Direct Current Stimulation (tDCS) is effective in the treatment of auditory hallucinations in schizophrenia.

Condition Intervention
Auditory Hallucinations
Procedure: active tDCS
Procedure: sham tDCS

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Participant, Investigator
Primary Purpose: Treatment
Official Title: Anodal & Cathodal tDCS for Treatment of Resistant Auditory Hallucinations in Schizophrenia

Resource links provided by NLM:

Further study details as provided by Hôpital le Vinatier:

Primary Outcome Measures:
  • Auditory hallucinations measured by Auditory Hallucination Rating Scale (Hoffman et al., 2003) [ Time Frame: before, after 1 week of treatment and 2 times follow up (1 & 3 months) ]

Secondary Outcome Measures:
  • Neurochemical impact of treatment measured by 1H-MRS (proton Magnetic Resonance Spectroscopy), DTI (Diffusion Tensor Imaging) and resting MRI [ Time Frame: 3 times: before treatment, immediately after treatment and a last evaluation 1 month after ]

Enrollment: 46
Actual Study Start Date: February 2, 2009
Study Completion Date: July 20, 2016
Primary Completion Date: April 21, 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: active tDCS

tDCS active; - Intensity = 2 milliamps (mA) during 20 minutes. ramp up/ramp down 30sec anodal tDCS applied over the left DLPFC combined with cathodal tDCS applied over the left temporoparietal junction (TPJ).

10 sessions, 2 per day

Procedure: active tDCS
Intensity 2 mA during 20 minutes, 2 times per day
Other Names:
  • tDCS
  • transDirect Current Stimulation
  • Anodal tDCS
  • Cathodal tDCS
Placebo Comparator: sham tDCS
tDCS placebo same electrode montage than in the active group. 30 sec of active tDCS in the beginning of the stimulation sessions; ramp up/ramp down 30 sec
Procedure: sham tDCS
sham condition as delivered by the stimulator
Other Name: tDCS placebo

Detailed Description:

The project will investigate the use of a novel technique, transcranial direct current stimulation (tDCS) in the treatment of patients with schizophrenia. tDCS permit the application of an extremely weak continuous electrical current to the brain through an anode and a cathode applied on the scalp. Anodal stimulation appears to increase brain activity whereas cathodal stimulation has the opposite effect.

Using anodal & cathodal tDCS the investigators aimed to treat auditory hallucinations, a symptoms of schizophrenia. The investigators plan to apply tDCS such that it can simultaneously increased activity in the frontal brain areas and reduce activity over temporoparietal cortex, 2 areas involved in the physiopathology of the disease. Real active stimulation will be compare to a sham condition in 60 patients (30 in each group). 30 patients will be included in a French center (Hospital le Vinatier, sponsor of the study) and 30 in Tunisia (laboratory "vulnerability to psychosis" (Pr Gaha) à Monastir).


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Schizophrenia according to Diagnostic and Statistical Manual - DSM-IV
  • Auditory verbal hallucinations for at least 6 weeks (despite antipsychotic drugs)
  • Medication Resistance according to Kane et al., 1988
  • Age between 18 and 50 years old
  • Informed consent

Exclusion Criteria:

  • Concomitant major and unstable medical or neurologic illness
  • Pregnant
  Contacts and Locations
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Please refer to this study by its identifier: NCT00870909

Hopital Le vinatier
Bron, France, 69677
Laboratoire de Recherche " Vulnérabilité Aux Psychoses "
Monastir, Tunisia
Sponsors and Collaborators
Hôpital le Vinatier
Principal Investigator: emmanuel poulet, MD, PhD Hopital Le Vinatier
Study Director: JEROME BRUNELIN, PhD Hopital le Vinatier
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Hôpital le Vinatier Identifier: NCT00870909     History of Changes
Other Study ID Numbers: 2008-A01226-49
Study First Received: March 26, 2009
Last Updated: February 28, 2017

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Perceptual Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on April 28, 2017