Jugular Venous Oxygen Saturation During Therapeutic Hypothermia After Cardiac Arrest (SjO2)

This study has been completed.
Information provided by (Responsible Party):
Davide Chiumello, Policlinico Hospital
ClinicalTrials.gov Identifier:
First received: March 10, 2009
Last updated: April 27, 2015
Last verified: April 2015
The purpose of this study is to understand what happens to cerebral metabolism during therapeutic hypothermia for hypoxic brain injury following cardiac arrest.

Condition Intervention
Hypoxic Brain Injury
Procedure: retrograde jugular venous cannulation

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Cerebral Metabolism During Therapeutic Hypothermia for Cardiac Arrest

Resource links provided by NLM:

Further study details as provided by Policlinico Hospital:

Biospecimen Retention:   Samples With DNA
whole blood

Enrollment: 15
Study Start Date: November 2011
Study Completion Date: December 2014
Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Intervention Details:
    Procedure: retrograde jugular venous cannulation
    Retrograde cannulation of jugular vein and intermittent sampling of venous blood from cerebral circulation before, during and after hypothermia.
    Other Name: SjO2, cerebrovenous oxygen saturation
Detailed Description:
Latest international guidelines recommend the use of therapeutic hypothermia in patients who have had cardiac arrest and remain in coma after return of spontaneous circulation. This is recommended essentially to limit the cerebral injury caused by cardiac arrest and possibly amplified upon reperfusion. At times, although a spontaneous circulation has returned, cerebral oxygenation may remain inadequate due to inadequate perfusion pressure, and hypothermia, by reducing cardiac output and cerebral blood flow could actually aggravate this phenomenon. The rewarming period is thought to be at greatest risk of inadequate oxygenation for the increase in metabolic demand. With this study we aim to understand what happens to cerebral oxygenation and metabolism during therapeutic hypothermia for cardiac arrest through cerebrovenous oxygen saturation monitoring and in particular, to see whether through this type of monitoring we could recognize otherwise unnoticed periods of inadequate cerebral oxygenation.

Ages Eligible for Study:   18 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Adult patients who are in coma after cardiac arrest, admitted to the Intensive Care Unit of a University Teaching Hospital and undergoing therapeutic hypothermia

Inclusion Criteria:

  • Adult patients in coma after cardiac arrest undergoing therapeutic hypothermia

Exclusion Criteria:

  • Age < 18
  • Pregnancy
  • Traumatic brain injury
  • Contraindications to cannulation as severe coagulopathy
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00870610

Intensive Care Unit-Fondazione Ospedale Maggiore Policlinico Mangiagalli Regina Elena
Milan, Italy, 20122
Sponsors and Collaborators
Policlinico Hospital
Principal Investigator: Davide Chiumello, MD Fondazione Ospedale Maggiore Policlinico Mangiagalli Regina Elena