Computer Stop Order Alert to Prevent Concurrent Prescribing of Trimethoprim/Sulfamethoxazole and Warfarin (warf-tmp/smx)

This study has been terminated.
(four adverse events encountered)
Information provided by (Responsible Party):
University of Pennsylvania Identifier:
First received: March 26, 2009
Last updated: December 7, 2015
Last verified: December 2015
To determine if a computerized stop order will reduce the number of concurrent trimethoprim/sulfamethoxazole and warfarin orders accepted through the inpatient electronic ordering system while a patient is hospitalized.

Condition Intervention
Prescribers' Drug Orders
Drug: Trimethoprim/Sulfamethoxazole and Warfarin

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Official Title: Randomized Controlled Study of a Computer Stop Order Versus Routine Practice When Trimethoprim/Sulfamethoxazole is Ordered Concurrently With Warfarin

Resource links provided by NLM:

Further study details as provided by University of Pennsylvania:

Primary Outcome Measures:
  • Reduce concomitant orders for warfarin and tmp/smx [ Time Frame: 7 months ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Determine if computerized stop order will increase risk for inadvertent cessation of warfarin [ Time Frame: 7 months ] [ Designated as safety issue: Yes ]
  • Determine if computerized stop order will increase risk of delay of treatment with tmp/sulfa when determined to be necessary for treatment [ Time Frame: 7 months ] [ Designated as safety issue: Yes ]

Enrollment: 1971
Study Start Date: August 2006
Study Completion Date: January 2007
Primary Completion Date: January 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: computerized alert
An automatic electronic stop of the tmp/sulfa or warfarin order whenever a resident or nurse practitioner places an order for tmp/sulfa with an already active warfarin order, or when ordering both simultaneously
Drug: Trimethoprim/Sulfamethoxazole and Warfarin
2 Current practice
Current practice of the pharmacist recommending cessation of concurrent warfarin and tmp/sulfa orders
Drug: Trimethoprim/Sulfamethoxazole and Warfarin


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

All resident physicians and nurse practitioners involved in inpatient care.

Exclusion Criteria:

  Contacts and Locations
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No Contacts or Locations Provided
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: University of Pennsylvania Identifier: NCT00870298     History of Changes
Other Study ID Numbers: 803788 
Study First Received: March 26, 2009
Last Updated: December 7, 2015
Health Authority: United States: Institutional Review Board

Keywords provided by University of Pennsylvania:
drug orders

Additional relevant MeSH terms:
Anti-Infective Agents
Anti-Infective Agents, Urinary
Antiparasitic Agents
Antiprotozoal Agents
Cytochrome P-450 CYP2C8 Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors
Folic Acid Antagonists
Molecular Mechanisms of Pharmacological Action
Renal Agents processed this record on May 26, 2016