Gut Hormone Secretion and Macronutrients
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|ClinicalTrials.gov Identifier: NCT00869453|
Recruitment Status : Completed
First Posted : March 26, 2009
Last Update Posted : July 3, 2012
The role of gut hormone (GLP-1, GIP, PYY...) in glucose homeostasis has been widely demonstrated. Furthermore modifications in their pattern of secretion seem to be involved in the improvement of glucose control in obese patients after bariatric surgery.
The purpose of this study is to assess the respective role of carbohydrate, fat and protein from a complete meal in gut hormones secretion.
|Condition or disease||Intervention/treatment|
|Healthy Volunteers||Other: test meal Other: glucose Other: fat Other: protein Other: control|
The study is designed to asses the role of each individual macronutrient of a compete meal in gut hormones secretion in healthy volunteers.
8 healthy young male subjects will be studied on 5 different occasions. To asses the role of each macronutient the subjects will recieve one of the following test meal: a complete sandwich, the proteic part of this complete meal, the glucidic part and the lipidic part. The fifth test will be a fasting test.
To assess the entero-insular axis, a 5.5 hours hyperglycaemic clamp will be performed.
|Study Type :||Observational|
|Actual Enrollment :||8 participants|
|Official Title:||Gut Hormone Secretion Pattern in Response to Different Macronutrients in Healthy Volunteers|
|Study Start Date :||March 2009|
|Primary Completion Date :||August 2009|
|Study Completion Date :||December 2009|
Other: test meal
Mixed meal containing bread, butter, beefOther: glucose
administration of a glucose mealOther: fat
administration of a lipid mealOther: protein
administration of a protein mealOther: control
- Gut hormone secretion [ Time Frame: within 4 hours following a test meal ]
- Entero-insular axis measurement [ Time Frame: within 4 hours following a test meal ]
- Glucose turnover [ Time Frame: 6 hours ]
- Insulin sensitivity [ Time Frame: 6 hours ]
- Substrate oxidation [ Time Frame: 6 hours ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00869453
|Cardiomet Clinical research Center, CHUV|
|Lausanne, VD, Switzerland, CH-1011|
|University of Lausanne|
|Lausanne, Switzerland, 1005|
|Principal Investigator:||Luc Tappy, MD||Centre Hospitalier Universitaire Vaudois|