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A Polymerase Chain Reaction (PCR) - Based Method to Improve Antibiotic Prescribing for Pneumonia

This study has been withdrawn prior to enrollment.
(funding issues and procedural problems)
The Physicians' Services Incorporated Foundation
Information provided by (Responsible Party):
Children's Hospital of Eastern Ontario Identifier:
First received: March 23, 2009
Last updated: February 24, 2016
Last verified: February 2016
Pneumonia, or lung infection, is usually treated with antibiotics targeted against the organisms that the physician guesses are causing the problem. The determination of the exact cause of a patient's pneumonia is difficult. The problem is that the two major causes of community-acquired pneumonia are not easily distinguished on clinical grounds and are best treated by different antibiotics. The investigators hypothesize that antibiotic therapy can be targeted and improved by doing polymerase chain reaction (PCR) testing of nose swabs to identify probable implicated organisms and their antibiotic resistance patterns. This pilot study will be important to ensure that the laboratory testing is functional and that the emergency department-laboratory communication is optimal prior to doing a full-fledged randomized clinical trial.

Condition Intervention
Procedure: nasopharyngeal swab

Study Type: Observational
Study Design: Observational Model: Ecologic or Community
Time Perspective: Prospective
Official Title: A Polymerase Chain Reaction-based Method to Improve Antibiotic Prescribing for Children and Adolescents With Community-Acquired Pneumonia - a Pilot Study

Resource links provided by NLM:

Further study details as provided by Children's Hospital of Eastern Ontario:

Biospecimen Retention:   Samples With DNA
nasopharyngeal swabs blood samples (for pneumococcal PCR)

Enrollment: 0
Groups/Cohorts Assigned Interventions
Children diagnosed with community-acquired pneumonia by the emergency department physician
Procedure: nasopharyngeal swab
PCR of NP swab for Mycoplasma, Chlamydophila, pneumococcus, pneumococcus macrolide resistance genes.


Ages Eligible for Study:   180 Days and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
children with community-acquired pneumonia presenting to the Children's Hospital of Eastern Ontario emergency department

Inclusion Criteria:

  • presumed community-acquired pneumonia as diagnosed by the attending emergency department physician

Exclusion Criteria:

  • age > 6 months
  • immunodeficiency (primary, advanced HIV)
  • cystic fibrosis
  • malignancy
  • known cardiac or lung defects
  • bronchiectasis
  • previous pneumonia or lung abscess in past 6 months
  • conditions requiring treatment with immune suppressants
  Contacts and Locations
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Please refer to this study by its identifier: NCT00867841

Canada, Ontario
Children's Hospital of Eastern Ontario
Ottawa, Ontario, Canada, K1H 8L1
Sponsors and Collaborators
Children's Hospital of Eastern Ontario
The Physicians' Services Incorporated Foundation
Principal Investigator: Jeffrey Pernica, MD Children's Hospital of Eastern Ontario/University of Ottawa
Study Director: Robert Slinger, MD Children's Hospital of Eastern Ontario/University of Ottawa
  More Information


Responsible Party: Children's Hospital of Eastern Ontario Identifier: NCT00867841     History of Changes
Other Study ID Numbers: CHEO-ID-001
Study First Received: March 23, 2009
Last Updated: February 24, 2016

Keywords provided by Children's Hospital of Eastern Ontario:
pneumonia, community-acquired
polymerase chain reaction
anti-bacterial agents

Additional relevant MeSH terms:
Lung Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Anti-Bacterial Agents
Anti-Infective Agents processed this record on May 25, 2017