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Frequency of Metabolic Syndrome in Down Syndrome Patients

This study has been completed.
Information provided by (Responsible Party):
ALEJANDRO ERNESTO MACIAS HERNANDEZ, Universidad de Guanajuato Identifier:
First received: March 17, 2009
Last updated: May 2, 2017
Last verified: May 2017
The aim of this study is to assess the frequency of metabolic syndrome in Down syndrome patients because the prevalence of diabetes mellitus and obesity is higher in individuals with Down syndrome than in the general population.

Metabolic Syndrome X
Down Syndrome

Study Type: Observational
Study Design: Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Prevalence of Metabolic Syndrome in Down Syndrome Patients

Resource links provided by NLM:

Further study details as provided by Universidad de Guanajuato:

Primary Outcome Measures:
  • To asses the frequency of the metabolic syndrome among Down syndrome patients. Metabolic syndrome was defined by Adult Treatment Panel III criteria modified by Halley-Castillo. [ Time Frame: One year ]

Secondary Outcome Measures:
  • Evaluate the insulin resistance and insulin sensitivity using the HOMA and QUICKY methods. [ Time Frame: One year ]

Biospecimen Retention:   Samples With DNA
Whole blood

Enrollment: 96
Actual Study Start Date: September 1, 2009
Study Completion Date: March 31, 2010
Primary Completion Date: December 21, 2009 (Final data collection date for primary outcome measure)
Patients with clinical and cytogenetics diagnosis of Down syndrome, between 7 - 24 years old.
Siblings of the same gender of the case, between 7-24 years old.


Ages Eligible for Study:   7 Years to 24 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Community sample

Inclusion Criteria:

  • Clinical diagnosis of Down syndrome

Exclusion Criteria:

  • History of congenital cardiac defects requiring open-heart surgery
  • History of gastroenterologic anomalies requiring bowel resection and/or ongoing medical intervention
  • History of leukemia or other cancer
  • History of hypothyroidism requiring thyroid hormone replacement
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Please refer to this study by its identifier: NCT00864461

School of Medicine, University of Guanajuato
Leon, Guanajuato, Mexico, 37320
Sponsors and Collaborators
Universidad de Guanajuato
  More Information

Responsible Party: ALEJANDRO ERNESTO MACIAS HERNANDEZ, MD, Universidad de Guanajuato Identifier: NCT00864461     History of Changes
Other Study ID Numbers: 249-08
Study First Received: March 17, 2009
Last Updated: May 2, 2017
Individual Participant Data  
Plan to Share IPD: No

Keywords provided by Universidad de Guanajuato:
Down syndrome
Metabolic syndrome X
Insulin resistance

Additional relevant MeSH terms:
Metabolic Syndrome X
Down Syndrome
Pathologic Processes
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn processed this record on May 25, 2017