Early Detection of Arteriosclerosis
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|ClinicalTrials.gov Identifier: NCT00863967|
Recruitment Status : Unknown
Verified March 2009 by Kantonsspital Baselland Bruderholz.
Recruitment status was: Active, not recruiting
First Posted : March 18, 2009
Last Update Posted : March 18, 2009
Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or peripheral arterial occlusive disease. In addition to life-style factors there is also a genetic predisposition to develop complicated atherosclerosis.
Objective: Improve individual risk prediction by clinical phenotyping and genotyping.
|Condition or disease|
|Arteriosclerosis Atherosclerosis Myocardial Infarction Stroke Diabetes Mellitus Peripheral Arterial Occlusive Disease|
About 300 patients who are treated for various conditions at the department of general medicine at our hospital will be included prospectively in the study. This observational cohort will be followed for at least 10 years follow-up examinations.
At baseline and during follow up visits detailed clinical phenotyping is planned (medical and family history,standardized clinical and physical examinations, lab, RX, ECG, stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes collected at baseline.
|Study Type :||Observational|
|Actual Enrollment :||269 participants|
|Official Title:||Prospective Observational Cohort Study for Early Detection of Arteriosclerosis|
|Study Start Date :||October 2003|
|Estimated Primary Completion Date :||October 2015|
|Estimated Study Completion Date :||October 2015|
no cardiovascular events
proven cardiovascular events
possible cardiovascular events
- Cardiovascular events [ Time Frame: 10 years at least ]
- Disease activity score [ Time Frame: 2 / 5 / 10 years ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00863967
|Principal Investigator:||Barbara Biedermann, MD||Medical Department Kantonsspital Bruderholz CH-4101 Bruderholz|