Early Detection of Arteriosclerosis
Recruitment status was: Active, not recruiting
Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or peripheral arterial occlusive disease. In addition to life-style factors there is also a genetic predisposition to develop complicated atherosclerosis.
Objective: Improve individual risk prediction by clinical phenotyping and genotyping.
Peripheral Arterial Occlusive Disease
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Prospective Observational Cohort Study for Early Detection of Arteriosclerosis|
- Cardiovascular events [ Time Frame: 10 years at least ] [ Designated as safety issue: No ]
- Disease activity score [ Time Frame: 2 / 5 / 10 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||October 2003|
|Estimated Study Completion Date:||October 2015|
|Estimated Primary Completion Date:||October 2015 (Final data collection date for primary outcome measure)|
no cardiovascular events
proven cardiovascular events
possible cardiovascular events
About 300 patients who are treated for various conditions at the department of general medicine at our hospital will be included prospectively in the study. This observational cohort will be followed for at least 10 years follow-up examinations.
At baseline and during follow up visits detailed clinical phenotyping is planned (medical and family history,standardized clinical and physical examinations, lab, RX, ECG, stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes collected at baseline.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00863967
|Principal Investigator:||Barbara Biedermann, MD||Medical Department Kantonsspital Bruderholz CH-4101 Bruderholz|