Early Detection of Arteriosclerosis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2009 by Kantonsspital Baselland Bruderholz.
Recruitment status was  Active, not recruiting
Information provided by:
Kantonsspital Baselland Bruderholz
ClinicalTrials.gov Identifier:
First received: March 17, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted

Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or peripheral arterial occlusive disease. In addition to life-style factors there is also a genetic predisposition to develop complicated atherosclerosis.

Objective: Improve individual risk prediction by clinical phenotyping and genotyping.

Myocardial Infarction
Diabetes Mellitus
Peripheral Arterial Occlusive Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Observational Cohort Study for Early Detection of Arteriosclerosis

Resource links provided by NLM:

Further study details as provided by Kantonsspital Baselland Bruderholz:

Primary Outcome Measures:
  • Cardiovascular events [ Time Frame: 10 years at least ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Disease activity score [ Time Frame: 2 / 5 / 10 years ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Whole blood / serum / white cells / plasma

Enrollment: 269
Study Start Date: October 2003
Estimated Study Completion Date: October 2015
Estimated Primary Completion Date: October 2015 (Final data collection date for primary outcome measure)
no cardiovascular events
proven cardiovascular events
possible cardiovascular events

Detailed Description:

About 300 patients who are treated for various conditions at the department of general medicine at our hospital will be included prospectively in the study. This observational cohort will be followed for at least 10 years follow-up examinations.

At baseline and during follow up visits detailed clinical phenotyping is planned (medical and family history,standardized clinical and physical examinations, lab, RX, ECG, stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes collected at baseline.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

teaching hospital primary care clinic


Inclusion Criteria:

  • 18 years and older
  • informed consent

Exclusion Criteria:

  • life-threatening disease
  • life expectancy < 1 month
  • uncapable to provide informed consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00863967

Sponsors and Collaborators
Kantonsspital Baselland Bruderholz
Principal Investigator: Barbara Biedermann, MD Medical Department Kantonsspital Bruderholz CH-4101 Bruderholz
  More Information


Responsible Party: Barbara Biedermann MD, Department of medicine, Kantonsspital Bruderholz, CH-4101 Bruderholz
ClinicalTrials.gov Identifier: NCT00863967     History of Changes
Other Study ID Numbers: KSBH: 216/03
Study First Received: March 17, 2009
Last Updated: March 17, 2009
Health Authority: Switzerland: Ethikkommission

Keywords provided by Kantonsspital Baselland Bruderholz:
physical examination
diagnostic techniques and procedures
immunologic tests
diagnostic tests
genetic test

Additional relevant MeSH terms:
Arterial Occlusive Diseases
Myocardial Infarction
Peripheral Arterial Disease
Cardiovascular Diseases
Heart Diseases
Myocardial Ischemia
Peripheral Vascular Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on October 06, 2015