We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu

Early Detection of Arteriosclerosis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00863967
Recruitment Status : Unknown
Verified March 2009 by Kantonsspital Baselland Bruderholz.
Recruitment status was:  Active, not recruiting
First Posted : March 18, 2009
Last Update Posted : March 18, 2009
Information provided by:
Kantonsspital Baselland Bruderholz

Brief Summary:

Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or peripheral arterial occlusive disease. In addition to life-style factors there is also a genetic predisposition to develop complicated atherosclerosis.

Objective: Improve individual risk prediction by clinical phenotyping and genotyping.

Condition or disease
Arteriosclerosis Atherosclerosis Myocardial Infarction Stroke Diabetes Mellitus Peripheral Arterial Occlusive Disease

Detailed Description:

About 300 patients who are treated for various conditions at the department of general medicine at our hospital will be included prospectively in the study. This observational cohort will be followed for at least 10 years follow-up examinations.

At baseline and during follow up visits detailed clinical phenotyping is planned (medical and family history,standardized clinical and physical examinations, lab, RX, ECG, stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes collected at baseline.

Study Type : Observational
Actual Enrollment : 269 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Observational Cohort Study for Early Detection of Arteriosclerosis
Study Start Date : October 2003
Estimated Primary Completion Date : October 2015
Estimated Study Completion Date : October 2015

no cardiovascular events
proven cardiovascular events
possible cardiovascular events

Primary Outcome Measures :
  1. Cardiovascular events [ Time Frame: 10 years at least ]

Secondary Outcome Measures :
  1. Disease activity score [ Time Frame: 2 / 5 / 10 years ]

Biospecimen Retention:   Samples With DNA
Whole blood / serum / white cells / plasma

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
teaching hospital primary care clinic

Inclusion Criteria:

  • 18 years and older
  • informed consent

Exclusion Criteria:

  • life-threatening disease
  • life expectancy < 1 month
  • uncapable to provide informed consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00863967

Sponsors and Collaborators
Kantonsspital Baselland Bruderholz
Principal Investigator: Barbara Biedermann, MD Medical Department Kantonsspital Bruderholz CH-4101 Bruderholz


Responsible Party: Barbara Biedermann MD, Department of medicine, Kantonsspital Bruderholz, CH-4101 Bruderholz
ClinicalTrials.gov Identifier: NCT00863967     History of Changes
Other Study ID Numbers: KSBH: 216/03
First Posted: March 18, 2009    Key Record Dates
Last Update Posted: March 18, 2009
Last Verified: March 2009

Keywords provided by Kantonsspital Baselland Bruderholz:
physical examination
diagnostic techniques and procedures
immunologic tests
diagnostic tests
genetic test

Additional relevant MeSH terms:
Diabetes Mellitus
Myocardial Infarction
Arterial Occlusive Diseases
Peripheral Arterial Disease
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Peripheral Vascular Diseases