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Immunohistochemical Expression Patterns of microRNA Processing Enzyme Dicer in Cutaneous Malignant Melanoma, Benign and Dysplastic Melanocytic Naevi

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ClinicalTrials.gov Identifier: NCT00862914
Recruitment Status : Completed
First Posted : March 17, 2009
Last Update Posted : October 16, 2012
Sponsor:
Information provided by (Responsible Party):
Michael Sand, Ruhr University of Bochum

Brief Summary:
MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study the researchers investigate the immunohistochemical distribution of Dicer in benign and dysplastic melanocytic naevi as well as in cutaneous malignant melanoma compared to intraindividual healthy control.

Condition or disease
Naevi Malignant Melanoma

Study Type : Observational
Actual Enrollment : 30 participants
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : July 2008
Actual Primary Completion Date : February 2009
Actual Study Completion Date : March 2009


Group/Cohort
1
benign melanocytic naevi
2
dysplastic melanocytic naevi
3
cutaneous malignant melanoma



Biospecimen Retention:   Samples With DNA
Paraffin embedded melanocytic skin lesion


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
dermatologic primary care clinic
Criteria

Inclusion Criteria:

  • Patients with benign melanocytic naevi, dysplastic melanocytic naevi and cutaneous malignant melanoma.

Exclusion Criteria:

  • Patients under 18 years of age
  • Patients with other forms of cancer in previous medical history
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00862914


Locations
Germany
Department of Dermatology and Allergology, Ruhr-University Bochum
Bochum, NRW, Germany, 44791
Sponsors and Collaborators
Ruhr University of Bochum
Investigators
Principal Investigator: Prof. Dr. Peter Altmeyer Department of Dermatology and Allergology, Ruhr-University Bochum
Study Director: PD Dr. Falk G. Bechara Department of Dermatology and Allergology, Ruhr-University Bochum

Publications of Results:
Responsible Party: Michael Sand, Dr., Ruhr University of Bochum
ClinicalTrials.gov Identifier: NCT00862914     History of Changes
Other Study ID Numbers: 006
First Posted: March 17, 2009    Key Record Dates
Last Update Posted: October 16, 2012
Last Verified: October 2012

Keywords provided by Michael Sand, Ruhr University of Bochum:
Skin
MicroRNA
miRNA
Dicer
Malignant Melanoma

Additional relevant MeSH terms:
Melanoma
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Nerve Tissue
Nevi and Melanomas