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CT-Based Versus Conventional Simulation for Palliative Radiotherapy of Non-Small Cell Lung Cancer

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ClinicalTrials.gov Identifier: NCT00862030
Recruitment Status : Completed
First Posted : March 16, 2009
Last Update Posted : August 8, 2011
Sponsor:
Information provided by:

Study Description
Brief Summary:
Radiotherapy (RT) treatment to the chest is a standard way of trying to decrease symptoms like cough or shortness of breath. Before any RT can be delivered, it must be planned, either using conventional x-rays ("fluoroscopy") or using computer tomography ("CT") scanning. This study is being done because the investigators do not know which of these two common ways of RT planning is better for balancing both treating the cancer and decreasing side effects.

Condition or disease Intervention/treatment
Non-small Cell Lung Cancer Procedure: CT- simulation scan

Detailed Description:
Standard RT planning will be performed under conventional simulation, followed by CT-simulation (for study purposes only). Retrospectively, 3D treatment fields will be designed using the CT-simulation data, and compared to the actual treatment fields planned using x-rays. Coverage of the tumour volume will be assessed, together with doses, field sizes and beam positions, to determine relative undercoverage of tumour and overcoverage of normal tissue between the two planning methods, if any.

Study Design

Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Comparison of Two-versus Three-Dimensional Treatment Planning for Patients Receiving Chest Radiotherapy for Symptom Control
Study Start Date : April 2009
Primary Completion Date : January 2011
Study Completion Date : January 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Lung Cancer
U.S. FDA Resources

Groups and Cohorts

Group/Cohort Intervention/treatment
1
Study Cohort
Procedure: CT- simulation scan
Patients who are receiving standard palliative radiotherapy planned under x-rays will also undergo 1 CT-simulation scan which they would otherwise not require. The planning x-rays and CT scan will then be compared dosimetrically


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
20
Criteria

Inclusion Criteria:

  • Patients with local symptoms secondary to histologically-confirmed non-small cell lung cancer
  • Patients who will be receiving palliative-intent external beam radiotherapy
  • Patients who are clinically appropriate for conventional radiotherapy planning
  • Patients who can provide written informed consent

Exclusion Criteria:

  • Patients who cannot provide written informed consent
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00862030


Locations
Canada, Alberta
Cross Cancer Institute
Edmonton, Alberta, Canada, T6G 1Z2
Sponsors and Collaborators
Alberta Health Services
Investigators
Principal Investigator: Dr. Alysa Fairchild, MD FRCPC AHS Cancer Control Alberta
More Information

Responsible Party: Dr.Alysa Fairchild, Alberta Cancer Board
ClinicalTrials.gov Identifier: NCT00862030     History of Changes
Other Study ID Numbers: 24639
First Posted: March 16, 2009    Key Record Dates
Last Update Posted: August 8, 2011
Last Verified: August 2011

Keywords provided by AHS Cancer Control Alberta:
Palliative radiotherapy
Treatment planning
Non-small cell lung cancer

Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Neoplasms
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms